Ibuprofen a non-steroidal anti-inflammatory drug (NSAID) is among the most prescribed drug on the world. Copper(II) complexes with NSAIDs are more active than their parent drugs and exhibit a lower toxicity than inorganic forms of copper [1] . Further, many of these complexes, including that of copper ibuprofenate complex, have a better anti-ulcer protective effect than the parent drugs. Binary...

Peganum harmala L. (Zygophyllaceae) is one of the most important medicinal plants had been used in traditional medicine in North of Iran as anti parasite, anti inflammatiom, anti tumor and anti infection. The aim of this study was to evaluate of ecological factors , ethno pharmacology and record of the relationship between secondary metabolites content and their antioxidant activity in seeds ex...

Eriolaena hookeriana is widely distributed in Central and southern India and is available in all parts of Andhra Pradesh. In present study, the roots of Eriolaena hookeriana were extracted by successive solvent extraction using Methanol and Water as solvents and the extracts were screened for anti inflammatory and analgesic activities on laboratory animals. Anti inflammatory activity was measur...

Objectives: To identify the active principles, determine the anti-diabetes activity of fraction of Stereospermum tetragonum root. Materials and Methods: The efficacy was evaluated in streptozotocin induced type 2 diabetic rats and the anti-hyperglycemic activity was studied by glucose tolerance test. The major active compounds were isolated by solvent fractionation and chromatographic technique...

Inflammation is a response to tissue damage due various adverse stimuli, both chemical and mechanical, infections foreign bodies such as bacteria viruses. This study aims determine the effect of anti-inflammatory ethanol extract karamunting stems. Karamunting stems were extracted by maceration method using 96% solvent. Each anti-inflamatory test was divided into five groups, namely negative con...

Chiral pyrrolidines and pyrrolizidines with spirooxindole ring systems are the central skeletons for numerous alkaloids and pharmacologically important compounds. Gelesmine, pseudotabersonine, formosanine, isoformosanine, morroniside and mitraphylline are some of the alkaloids containing spirooxindole ring systems. Derivatives of spirooxindole find very wide biological applications as anti micr...

BACKGROUND Costus speciosus, Cymbopogon citratus, and Tabernaemontana coronaria are herbal plants traditionally used as remedies for symptoms of tuberculosis (TB) including cough. The aims of the present study were to evaluate the in vitro anti-TB activity of different solvent partitions of these plants, to identify the phytochemical compounds, and to assess the effects of the most active parti...

Dojuksan is a traditional herbal medicine used in Korea and China to treat urinary diseases. In the present study, we aimed to examine the anti-inflammatory effects of an ethanol solvent extract of Dojuksan and a fraction (by bioassay-guided fractionation) derived from this extract, and to elucidate the specific mechanisms involved. The Dojuksan 30% ethanol extract (DEE) had a more significant ...

Chiral pyrrolidines and pyrrolizidines with spirooxindole ring systems are the central skeletons for numerous alkaloids and pharmacologically important compounds. Gelesmine, pseudotabersonine, formosanine, isoformosanine, morroniside and mitraphylline are some of the alkaloids containing spirooxindole ring systems. Derivatives of spirooxindole find very wide biological applications as anti micr...

Chalcones, or 1,3–diaryl–2–propen–1–ones, one of the major classes of natural products and posses many useful properties like anticancer, antibacterial, antifungal, anti–inflammatory, antimalarial and anti–diabetic activity. We report in this communication the synthesis and anticancer study of a number of novel chalcone sulfonamides. Our results indicate that the synthesis of chalcone sulfonami...