نتایج جستجو برای: and ns5a proteins

تعداد نتایج: 16874701  

2017

-------------------------------INDICATIONS AND USAGE------------------------VOSEVI is a fixed-dose combination of sofosbuvir, a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor, velpatasvir, an HCV NS5A inhibitor, and voxilaprevir, an HCV NS3/4A protease inhibitor, and is indicated for the treatment of adult patients with chronic HCV infection without cirrhosis or with compen...

Journal: :Virology 2011
Choongho Lee Han Ma Julie Qi Hang Vincent Leveque Ella H Sklan Menashe Elazar Klaus Klumpp Jeffrey S Glenn

The hepatitis C virus (HCV) non-structural (NS) 5A protein plays an essential role in the replication of the viral RNA by the membrane-associated replication complex (RC). Recently, a putative NS5A inhibitor, BMS-790052, exhibited the highest potency of any known anti-HCV compound in inhibiting HCV replication in vitro and showed a promising clinical effect in HCV-infected patients. The precise...

پایان نامه :دانشگاه تربیت معلم - تهران - دانشکده زیست شناسی 1391

بررسی تآثیر کورکومین بر بیان آکواپورین5 در سلول های سرطانی روده بزرگ انسان(ht-29) سرطان روده بزرگ جزو بیماری های خطرناک بوده و از نظر شیوع سومین سرطان شایع و دومین علت مرگ ومیر ناشی از سرطان در جهان محسوب می شود. خطرابتلا به این سرطان تحت تاثیر دو عامل محیطی وفاکتورهای ژنتیکی می باشد. آکواپورین ها، پروتئین های کانال آبی بوده که نقش مهمی را در انتقال آب در بافتهای اندوتلیالی و اپی تلیالی بر عهد...

Journal: :Journal of chemical biology 2011
Lyn H Jones David Beal Matthew D Selby Owen Everson George M Burslem Peter Dodd Jared Millbank Thien-Duc Tran Florian Wakenhut Emily J S Graham Paul Targett-Adams

UNLABELLED Small molecule fluorometric boron dipyrromethene probes were developed to bind hepatitis C virus-encoded NS5A protein and aid subcellular distribution studies. These molecules did not co-locate with NS5A, therefore alternative 'silent' azide reporters were used to obtain a more relevant picture of their distribution. Following pre-incubation with replicon cells, click chemistry was u...

2017
Jihui Lin Chengbao Wang Longxiang Zhang Tao Wang Jing Zhang Wulong Liang Cheng Li Gui Qian Yueling Ouyang Kangkang Guo Yanming Zhang

Classical swine fever virus (CSFV) is a fatal pig pestivirus and causes serious financial losses to the pig industry. CSFV NS4B protein is one of the most important viral replicase proteins. Rab5, a member of the small Rab GTPase family, is involved in infection and replication of numerous viruses including hepatitis C virus and dengue virus. Until now, the effects of Rab5 on the proliferation ...

Journal: :Antimicrobial agents and chemotherapy 2012
Chunfu Wang Lingling Jia Haichang Huang Dike Qiu Lourdes Valera Xin Huang Jin-Hua Sun Peter T Nower Donald R O'Boyle Min Gao Robert A Fridell

The antiviral profile of BMS-790052, a potent hepatitis C virus (HCV) replication complex inhibitor targeting nonstructural protein NS5A, is well characterized for HCV genotype-1. Here, we report that BMS-790052 inhibits hybrid replicons containing HCV genotype-4 NS5A genes with 50% effective concentrations (EC(50)s) ranging from 7 to 13 pM. NS5A residue 30 was an important site for BMS-790052-...

Journal: :hepatitis monthly 0
sadaf badar national centre of excellence in molecular biology, university of the punjab, pakistan sadaf badar national centre of excellence in molecular biology, university of the punjab, lahore, pakistan bushra khubaib national centre of excellence in molecular biology, university of the punjab, pakistan bushra khubaib national centre of excellence in molecular biology, university of the punjab, lahore, pakistan muhammad idrees national centre of excellence in molecular biology, university of the punjab, pakistan +92-425293141, [email protected]; national centre of excellence in molecular biology, university of the punjab, pakistan +92-425293141, [email protected] muhammad idrees national centre of excellence in molecular biology, university of the punjab, lahore, pakistan; corresponding author at: muhammad idrees, national centre of excellence in molecular biology, 87-west canal bank, road thokar niaz baig lahore-53700, university of the punjab, lahore, pakistan. tel.: + 92-425293141, fax: +92-425293149, e-mail:

context hcv infection is strongly associated with development of insulin resistance and type-2 diabetes, however molecular mechanism of these associations is not known. the aim of this review was to conduct a comprehensive literature search to understand the nature of the association between hepatitis c virus (hcv) infection and insulin resistance (ir). we also explored the role of hcv core pro...

Journal: :Angewandte Chemie 2021

The Hepatitis C virus nonstructural protein 5A (NS5A) is a membrane-associated involved in multiple steps of the viral life cycle. Direct-acting antivirals (DAAs) targeting NS5A are cornerstone antiviral therapy, but mode-of-action these drugs poorly understood. This due to lack information on membrane-bound structure. Herein, we present structural model an AH-linker-D1 reconstituted as proteol...

2017
Zhao Li Zhi-wei Chen Hu Li Hong Ren Peng Hu

Background Direct-acting antivirals (DAAs) against hepatitis C virus (HCV) are potent and highly efficacious. However, resistance-associated substitutions (RASs) relevant to DAAs can impair treatment effectiveness even at baseline. Moreover, the prevalence of baseline RASs in HCV genotype 1b-infected patients in western China is still unclear. Materials and methods Direct sequencing of the HC...

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