نتایج جستجو برای: anaplastic lymphoma kinase

تعداد نتایج: 333698  

Journal: :Molecular bioSystems 2014
Tatyana G Karabencheva Christian C Lee Gary W Black Rossen Donev Christo Z Christov

Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently occurring and clinically important activation mutants we revealed important conformational effects on key interactions responsible for the activation o...

2013
Justin F. Gainor Anna M. Varghese Sai-Hong Ignatius Ou Sheheryar Kabraji Mark M. Awad Ryohei Katayama Amanda Pawlak Mari Mino-Kenudson Beow Y. Yeap Gregory J. Riely Maria E. Arcila Marc Ladanyi Jeffrey A. Engelman Alice T. Shaw

Purpose: Anaplastic lymphoma kinase (ALK) gene rearrangements define a distinct molecular subset of non–small cell lung cancer (NSCLC). Recently, several case reports and small series have reported that ALK rearrangements can overlap with other oncogenic drivers in NSCLC in crizotinib-na€ ve and crizotinib-

ژورنال: پژوهش در پزشکی 2010
بلوری، , ناصر, جعفری , مجید, راعی , محمدرضا, رخشان، , آزاده, صولت , فرید, مرادی, افشین, ژام, هانیه,

Abstract Background: Hodgkin's lymphoma (HL) is a curable lymphoid malignancy. Different Immunohistochemical markers specially CD15 & CD30 are used to diagnose HL and differentiate it from other lymphomas including anaplastic large cell lymphoma (ALCL) regarding different reports on the frequency of immunoreactivity for these markers in the literature and lack of information in this regard...

Journal: :Cancer discovery 2014
Suresh S Ramalingam Fadlo R Khuri

Ceritinib and other second-generation inhibitors have demonstrated promising anticancer activity in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). Specifically, they can overcome resistance due to certain gatekeeper mutations acquired following crizotinib exposure. These agents now provide new options for the management of ALK-positive NSCLC.

Journal: :Mechanisms of Development 2009
Minoru Omi Hidekiyo Harada Harukazu Nakamura

the embryo, consistent with a shared origin of these cell-types. We also present evidence that iridophore precursors are likely to also have glial potential. Finally, we engineered constitutively active form of ltk gene by analogy with oncogenic gene nucleophosmin-anaplastic lymphoma kinase, and examine the results from experiments asking what happens to NCCs with constitutively active Ltk sign...

2012
Jae Wook Kim Su-Jin Shin Chan-Jeoung Park

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 53-year-old woman had multiple bilateral axillary and left supraclavicular lymph-node (LN) enlargements for 6 months. LN biopsy revealed anaplastic large-cell lymphoma (ALCL) that was anaplastic lymphoma kinase (ALK)-negative (A. typical " hallmark " cell:...

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