نتایج جستجو برای: anaplastic lymphoma kinase
تعداد نتایج: 333698 فیلتر نتایج به سال:
Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently occurring and clinically important activation mutants we revealed important conformational effects on key interactions responsible for the activation o...
Purpose: Anaplastic lymphoma kinase (ALK) gene rearrangements define a distinct molecular subset of non–small cell lung cancer (NSCLC). Recently, several case reports and small series have reported that ALK rearrangements can overlap with other oncogenic drivers in NSCLC in crizotinib-na€ ve and crizotinib-
Abstract Background: Hodgkin's lymphoma (HL) is a curable lymphoid malignancy. Different Immunohistochemical markers specially CD15 & CD30 are used to diagnose HL and differentiate it from other lymphomas including anaplastic large cell lymphoma (ALCL) regarding different reports on the frequency of immunoreactivity for these markers in the literature and lack of information in this regard...
Ceritinib and other second-generation inhibitors have demonstrated promising anticancer activity in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). Specifically, they can overcome resistance due to certain gatekeeper mutations acquired following crizotinib exposure. These agents now provide new options for the management of ALK-positive NSCLC.
the embryo, consistent with a shared origin of these cell-types. We also present evidence that iridophore precursors are likely to also have glial potential. Finally, we engineered constitutively active form of ltk gene by analogy with oncogenic gene nucleophosmin-anaplastic lymphoma kinase, and examine the results from experiments asking what happens to NCCs with constitutively active Ltk sign...
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 53-year-old woman had multiple bilateral axillary and left supraclavicular lymph-node (LN) enlargements for 6 months. LN biopsy revealed anaplastic large-cell lymphoma (ALCL) that was anaplastic lymphoma kinase (ALK)-negative (A. typical " hallmark " cell:...
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