BACKGROUND Antihypertensive treatment mitigates the progression of chronic kidney disease. Here, we comparatively assessed the effects of antihypertensive agents in normotensive and hypertensive diabetic patients with microalbuminuric kidney disease. METHODS MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched for randomized controlled trials (R...

OBJECTIVE We evaluated the optimal dose of the angiotensin II receptor antagonist candesartan cilexetil for renoprotection as reflected by short-term changes in albuminuria in hypertensive type 2 diabetic patients with nephropathy. RESEARCH DESIGN AND METHODS A total of 23 hypertensive patients with type 2 diabetes and nephropathy were enrolled in this double-blind randomized cross-over trial...

BACKGROUND Albuminuria is an important risk factor for progressive chronic kidney disease (CKD) and is more prevalent in black than white adults. We sought to determine the association between low income and albuminuria and whether this association differs for blacks and whites. STUDY DESIGN Cross-sectional study. SETTING & PARTICIPANTS 9,144 black and 13,684 white US adults 45 years and ol...

BACKGROUND Lower estimated glomerular filtration rate is associated with reduced life expectancy. Whether this association is modified by the presence or absence of albuminuria, another cardinal finding of chronic kidney disease, is unknown. OBJECTIVE Our objective was to estimate the life expectancy of middle-aged men and women with varying levels of eGFR and concomitant albuminuria. DESIG...

Introduction: Diabetes mellitus is one of the commonest non-communicable diseases in Nepal and associated with long term microvascular macro vascular complications. Detection albumin urine earliest recognizable feature development proteinuric diabetic nephropathy. This study aims to prevalence as well determinants albuminuria patient Type 2 diabetes visiting medical OPD College Medical Sciences...

OBJECTIVE High rates of albuminuria are observed among HIV-infected individuals on stable antiretroviral therapy (ART). Though pro-inflammatory and pro-fibrotic responses are described as components of albuminuria in the general population, it is unclear how these responses are associated to albuminuria in ART-treated chronic HIV. We investigated the relationship of monocyte subsets and urine i...

OBJECTIVE We investigated in a cross-sectional study the levels of serum and urinary damage markers in diabetic patients (n = 94) and nondiabetic control subjects (n = 45) to study the association of glomerular (IgG), proximal tubular (kidney injury molecule [KIM]-1, N-acetyl-β-d-glucosaminidase [NAG], neutrophil gelatinase-associated lipocalin [NGAL], and cystatin C), and distal tubular (heart...

Retinal arteriolar narrowing reflects aging, hypertension, chronic kidney disease (CKD), and other vascular processes. We examined the predictive value of retinal arteriolar narrowing alone and in combination with albuminuria on renal disease progression in CKD. A white CKD stage 2 to 4 cohort of 164 men and women (60.8±13.8 years) underwent retinal photography and determination of albuminuria....

results the prevalence of micro and macroalbuminuria was 17.2% and 17.6%, respectively. microalbuminuria was significantly associated with longer diabetes duration, increased fasting plasma glucose, and diastolic blood pressure. it was also found that higher plasma glucose and bun (blood urea nitrogen) were risk factors for macroalbuminuria. conclusions prevalence of both micro- and macroalbumi...

conclusions our study indicated that ace-d and vegf-g alleles can be an independent risk factor for microalbominuria in t2dm patients. results a total of 255 consecutive patients with t2dm and microalbuminuria (group a) and 235 patients with t2dm and normoalbuminuria (group b) were included in the study. in univariate analysis, the groups were statistically similar for all variables, except for...