introduction:mediastinum contains different vital structures that are located in the anterior and middle or posterior compartments. various types of mediastinal masses or tumors can be seen in the mediastinum. materials and methods:this case series study was performed on 95 patients who had referred to mashhad university of medical sciences between 1990 and 2010 were reviewed. the inclusion cri...

in the present study the effect of the locally produced genetic adjuvant of ginea pig specific cpg-motif-containing oligodeoxynucleotide (cpg-odn) in an inactivated fmd virus vaccine was evaluated. boosting the ginea pigs with fmd vaccine along with cpg-odn adjuvant produced relatively higher ratio (5-fold) of fmdv-specific igg2a / igg1 than those vaccinated in the absence of cpg-odn. the neutr...

introduction: an effective vaccine against hcv infection is not available. the non-structural protein 3 (ns3) of the virus as an important immunogenic candidate has been utilized in various modules. nanostructured polymers have been recently used for efficient vaccine and drug delivery. the aim of the current study was the synthesis of rns3-g2 conjugate and preliminary evaluation of its immunog...

background: nanoparticles have been considered as promising tools because of their high applicability. recently, nanoparticles have been evaluated for their ability to increase the immune responses as adjuvants. silver-nanoparticles (agnps) have shown promising results in enhancing th-2 immune responses and to produce potent neutralizing antibodies. neutralizing antibodies are considered as the...

Sheep pox and enterotoxemia are important diseases of sheep, and these diseases cause severe economic losses to sheep farmers. The present study was undertaken to evaluate the potential of formaldehyde-inactivated recombinant epsilon toxin as a vaccine candidate. The potency of the recombinant epsilon toxoid with aluminum hydroxide as an adjuvant in sheep was determined. Vaccinated sheep were p...

Epidemiological and experimental studies have convincingly demonstrated that n-3 polyunsaturated fatty acids (PUFAs) inhibit the initiation and progression stages of colorectal cancer. Attenuation of cell proliferation and induction of apoptosis by modulation of multiple signaling pathways makes n-3 PUFAs a promising candidate for chemoprevention as well as a dietary adjuvant with other antican...

compared to other methods of vaccine production, (e.g. culture flask and bioreactor system), the roller culture method for producing rabies vaccine is simpler, and the equipment easier to install and maintain, and also in the event of contamination of one roller, the entire batch need not be discarded. this system provides a much larger surface area than the culture flask, and also ensures a mu...

adjutants' ability in enhancing the performance of herbicides is a major priority in adjuvant research. to identify an appropriate adjuvant for pinoxaden and clodinafop propargyl herbicides against littleseed canarygrass (phalaris minor retz.), common wild oat (avena fatua l.) and ryegrass (lolium temulentum l.), three separate experiments were conducted under greenhouse conditions. in all...

  Introduction : Designing an effective vaccine against human immunodeficiency virus (HIV)-1 is a global health priority . Multi-epitope vaccines offer several potential advantages that may be promising in case of mutable divergent pathogens such as HIV-1. Herein, a multiepitopic recombinant protein containing various HIV-1 antigens was expressed in E. coli cells and its immunogenicity in combi...

objective the goal of this study was to prepare and characterize alginate microspheres as an antigen delivery system and adjuvant for immunization against leishmaniasis. materials and methods microspheres were prepared by an emulsification technique and characterized for size, encapsulation efficiency, and release profile of encapsulates. selection of appropriate parameters (viscosity of algina...