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The post-translational farnesylation of proteins serves to anchor a subset of intracellular proteins to membranes in eukaryotic organisms and also promotes protein-protein interactions. Inhibition of protein farnesyltransferase (PFT) is lethal to the pathogenic protozoa Plasmodium falciparum. Parasites were isolated that were resistant to BMS-388891, a tetrahydroquinoline (THQ) PFT inhibitor. R...
Whilst this target will hopefully be achieved, we should not overlook the fact that an estimated 837 million people are presently living in slums and that this is expected to double within 25 years. This suggests that the total number of people living in slums by 2020 will be about 1500 million, so a reduction of 100 million is modest by any definition. It also suggests that an equal or even gr...
At NIRS-HIMAC, by the end of July 2000, 837 patients have already been treated using carbon beams. One of the recent developments is a smaller number of fractionation. Actual fractionation is 4 times per week for Liver, and is 9 times per 3 weeks for Lung. The required beam intensity has thus increased up to 300 eμA of C at the source and 2×10 pps of C at the isocenter. Furthermore, since the i...
CAN J ANESTH 55: 6 www.cja-jca.org June, 2008 References 1 Melarkode K, Prinzhausen H. Hemoglobin M variant and congenital methemoglobinemia: methylene blue will not be effective in the presence of hemoglobin M. Can J Anesth 2008; 55: 129–30. 2 Schweitzer SA. Spurious pulse oximeter desaturation due to methaemoglobinaemia. Anaesth Intensive Care 1991: 19: 269–71. 3 Cassady G. Transcutaneous mon...
Lutzomyia spp. are New World phlebotomine sand flies, many of which are involved in the transmission of human diseases, such as leishmaniases and bartonellosis. The systematic classification of the approximately 400 species in the genus has been based on morphological characters, but the relationships within the genus are still very much in question. We have inferred phylogenies of 32 species o...
This study examined the effects of multiple risk, promotive, and protective factors on three achievement-related measures (i.e., grade point average, number of absences, and math achievement test scores) for African American 7th-grade students (n = 837). There were 3 main findings. First, adolescents had lower grade point averages, more absences, and lower achievement test scores as their expos...
Rationale: Failing cardiomyocytes exhibit decreased efficiency of excitation-contraction (E-C) coupling. The downregulation of junctophilin-2 (JP2), a protein anchoring the sarcoplasmic reticulum to T-tubules, has been identified as a major mechanism underlying the defective E-C coupling. However, the regulatory mechanism of JP2 remains unknown. Objective: To determine whether microRNAs regulat...
The substrate depletion approach is an increasingly popular alternative to the traditional method (observing product formation) of determining the kinetic parameters (KM and Vmax) of an enzyme. Obach and Reed-Hagen (Drug Metab Dispos 30:831-837, 2002) used an empirical relationship between substrate depletion rate constants and initial substrate concentration to determine kinetic parameters for...
We present a full account detailing the development of a sequential catalysis strategy for the synthesis of chiral b-alkynyl carbonyl and sulfonyl derivatives. A palladium-catalyzed cross coupling of terminal alkyne donors with acetylenic ester, ketone, and sulfone acceptors generates stereodefined enynes in high yield. These compounds are engaged in an unprecedented, regioand enantioselective ...
Scaffold proteins bind to and functionally link protein members of signaling pathways. Interaction of the scaffold proteins, myosin phosphatase target subunit (MYPT1) and myosin phosphatase-RhoA interacting protein (MRIP), causes co-localization of myosin phosphatase and RhoA to actomyosin. To examine biophysical properties of interaction of MYPT1 with MRIP, we employed analytical ultracentrifu...
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