Background and aim: Colon cancer is the third most prevalent cancer in Iran. Prolonged colon inflammation is an important factor, in the development of colon cancer. Ginger has anti-inflammatory properties due to its content of [6]-gingerol and hence can play a role in the prevention of colon cancer. In this research the effects of ginger extract on reducing expression of the C...

objective: multiple sclerosis (ms) is a chronic autoimmune disease due to demyelination of the central nervous system. it is believed that cytokines are involved in the pathogenesis of ms. the interleukin-2 (il2) gene is powerful functional candidate that is involved in immune regulation and operation. in this study, for the first time, we investigated the effect of -475 a/t and -631 g/a il2 po...

background: angiotensin i converting enzyme (ace) is a zinc metalloproteinase, converts ang-i to ang- ii, a pro-inflammatory agent which may contribute to pathophysiology of some diseases like type 2 diabetes. objective: to investigate the relationship between ace i/d polymorphism and type 2 diabetes in 261 iranian casecontrol pairs. methods: 170 patients (85 type 2 diabetics with nephropathy a...

diabetes mellitus is a multifactorial disease. it has recently been shown that an insertion (i)/deletion (d) polymorphism exists in the angiotensin-converting enzyme (ace) gene that can affect the serum ace level. there are three genotypes: dd, di, and ii, with the ace level being highest in dd, intermediate in di, and lowest in ii. in the present investigation, 170 patients with type 2 diabete...

Sotos syndrome is a rare genetic disorder with autosomal dominant inheritance, marked by overgrowth macrocephaly, distinctive facial appearance, and intellectual impairment. It occurs due to pathogenic variants encompassing the NSD1 gene. In addition, Sotos-like syndromes are also recognized, including Malan syndrome, known as type 2, which caused NFIX gene.
 Herein we present series of 3 ...

Background and Objectives: Apoptosis plays a key role in pathogenesis of various cardiovascular diseases due to loss of terminally differentiated cardiac myocytes. Therefore, the aim of this study was to investigate effects of combined dietary restriction and aerobic training on indices of myocardial apoptosis in male rats. Materials and Methods: In this study, 32 three-month-old male rats wer...