Melanoma is a very aggressive tumor that arises from melanocytes. Late stage and widely spread diseases do not respond to standard therapeutic approaches. The kallikrein-kinin system (KKS) participates in biological processes such as vasodilatation, pain and inflammatory response. However, the role of KKS in tumor formation and progression is not completely understood. The role of the host kini...

Purpose: To show the effect and the increased scan efficiency offered by DREAM-based B1 + shimming in fast whole body fat/water imaging at 3T. Introduction: High field whole-body imaging is a promising technique for quantitative MRI. However, at 3T and above, wave propagation effects can have serious effects on RF field homogeneity (B1 ). This results in spatially varying image contrast and SNR...

Introduction MRI spine imaging at 3T has been found to offer improvement over 1.5T in terms of SNR and tissue delineation, but with new challenges related to B1 and B0 inhomogeneity [1]. At 7T there is an additional problem of a lack of commercially available RF coils and the opposite twisting of B1 and B1 [2] complicates coil design. Recently, Kraff et al demonstrated an 8 channel transceive a...

The mechanisms responsible for the generation of a mature B1 and B2 cell compartment are still poorly understood. In this study, we demonstrated that absence of Dickkopf-3 (DKK3) led to changes in the composition of the B cell compartment, which were due to an altered development and maintenance program of B cells. Development of B2 cells was impaired at the pre-and immature B cell stage, resul...

The Descartes circle theorem states that if four circles are mutually tangent in the plane, with disjoint interiors, then their curvatures (or “bends”) bi = 1 ri satisfy the relation (b1 + b2 + b3 + b4) 2 = 2(b1 + b 2 2 + b 2 3 + b 2 4). We show that similar relations hold involving the centers of the four circles in such a configuration, coordinatized as complex numbers, yielding a complex Des...

PURPOSE Cyclin B1 plays an important role in control of the G(2)-M transition of the cell cycle. We have shown recently that overexpression of cyclin B1 is associated with poor outcome in patients with early stage squamous cell carcinoma (SCC) of the lung. EXPERIMENTAL DESIGN To determine the role of cyclin B1 in SCC of the tongue, we analyzed tumor specimens from 41 patients with stage II-IV...

There is increasing evidence that the biological function of vitamin B1 is concerned with oxidative processes in the living organism. In studies of oxygen utilization by manometric methods, Peters and his coworkers (1, 2) have shown that there is increased oxygen uptake by deficient brain and kidney tissues in vitro following the addition of vitamin B1. In the same laboratory Thompson and Johns...

and Applied Analysis 3 −0.4 −0.3 −0.2 −0.1 0 0.1 0.2 0.3 0.4 −1.5 −1 −0.5 0 0.5 1 1.5 x1 x 2 Figure 1: Phase portrait of the chaotic YangHenon map system with a1 1.4, b1 0.3. where a1 1.4, b1 0.3 and positive argument n1 0, 1, 2, 3, . . . , n. The Yang chaotic behaviors of Henon map system are quoted 19 by phase portraits in Figure 1. The Henon map system is invertible if b1 / 0. The inversed H...

The semaphorin 4D (Sema4D) receptor plexin-B1 constitutively interacts with particular Rho guanine nucleotide exchange factors (RhoGEFs) and thereby mediates Sema4D-induced RhoA activation, a process which involves the tyrosine phosphorylation of plexin-B1 by ErbB-2. It is, however, unknown how plexin-B1 phosphorylation regulates RhoGEF activity. We show here that activation of plexin-B1 by Sem...