Canonical microRNA biogenesis requires the Microprocessor components, Drosha and DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The Microprocessor is not required for processing of some miRNAs, including mirtrons, in which spliceosome-excised introns are direct Dicer substrates. In this study, we examine the processing of putative human mirtrons and demonstrate that althoug...

syndrome. In: Grudzinskas JG, Chard T, Chapman M, Cuckle HS, eds. Cambridge: Cambridge University Press, 1993 (in press). 25 Laundon C, Spencer K, Macri JN, Buchanan P. Tumer syndrome detection by MSAFP/Free Beta (hCG) screening. J Med Genet 1993;30:340-1. 26 Spencer K, Mallard AS, Coombes EJ, Macri JN. Prenatal screening for trisomy 18 with free f3 human chorionic gonadotrophin. BMJ 1993 (in p...

OBJECTIVE To determine the prevalence and risk factors for hepatitis B virus (HBV) infections among individuals attending an STD clinic in a low endemic region. STUDY DESIGN A total of 1228 women and 1648 men attending the STD clinic at the University Hospital Rotterdam, Netherlands, were examined for HBV infection by determination of hepatitis B surface antigen (HBsAg) and antibodies to hepa...

Motivation: Microarray experiments generate large datasets with expression values for thousands of genes but not more than a few dozens of samples. Accurate supervised classification of tissue samples in such high-dimensional problems is difficult but often crucial for successful diagnosis and treatment. A promising way to meet this challenge is by using boosting in conjunction with decision tr...

728 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 20, No. 4, April 2014 4. Ross PJ, Jacobson J, Muir JR. Q fever endocarditis of porcine xenograft valves. Am Heart J. 1983;105:151–3. http://dx.doi. org/10.1016/0002-8703(83)90293-4 5. al-Hajjar S, Hussain Qadri SM, al-Sabban E, Jager C. Coxiella burnetii endocarditis in a child. Pediatr Infect Dis J. 1997;16:911–3. http://dx.doi. org/10....

Recent developments in microfabrication and nanotechnology will enable the inexpensive manufacturing of massive numbers of tiny computing elements with sensors and actuators. New programming paradigms are required for obtaining organized and coherent behavior from the cooperation of large numbers of unreliable processing elements that are interconnected in unknown, irregular, and possibly time-...

Pressure ulcers are a significant iatrogenic cause of morbidity and mortality in the aged care population, with prevalence reported to be as high as 43% in some aged care facilities. The PRIME trial was a 15-month preand post-intervention study designed to investigate the effectiveness of an integrated pressure ulcer management system consisting of pressure ulcer risk assessment tools, Australi...

BACKGROUND Platelet glycoprotein (GP) IIb/IIIa antagonists prevent the composite end point of death or myocardial infarction (MI) in patients with acute coronary syndromes. There is uncertainty about whether this effect is confined to patients who have percutaneous coronary interventions (PCIs) and whether PCIs further prevent death or MI in patients already treated with GP IIb/IIIa antagonists...

UNLABELLED Nonalcoholic fatty liver disease (NAFLD) is an escalating health problem that is frequently associated with obesity and insulin resistance. The mechanistic relationship between NAFLD, obesity, and insulin resistance is not well understood. A nonsynonymous variant in patatin-like phospholipase domain containing 3 (rs738409, I148M) has been reproducibly associated with increased hepati...

We investigated the influence of the level of cognitive functioning on sequence-specific learning in Parkinson's disease (PD). This was done by examining the relationship between the scales for outcomes in Parkinson's disease-cognition [SCOPA-COG, Marinus, J., Visser, M., Verwey, N. A., Verhey, F. R. J., Middelkoop, H. A. M.,Stiggelbout, A., et al. (2003). Assessment of cognition in Parkinson's...