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The human genome project has been recently complemented by whole-genome assessment sequence of 32 mammals and 24 nonmammalian vertebrate species suitable for comparative genomic analyses. Here we anticipate a precipitous drop in costs and increase in sequencing efficiency, with concomitant development of improved annotation technology and, therefore, propose to create a collection of tissue and...
SUMMARY ALOHOMORA is a software tool designed to facilitate genome-wide linkage studies performed with high-density single nucleotide polymorphism (SNP) marker panels such as the Affymetrix GeneChip(R) Human Mapping 10K Array. Genotype data are converted into appropriate formats for a number of common linkage programs and subjected to standard quality control routines before linkage runs are st...
Aims. We present the analysis of the U − V rest-frame color distribution and some spectral features as a function of mass and environment for a sample of early-type galaxies up to z = 1 extracted from the zCOSMOS spectroscopic survey. This analysis is used to place constraints on the relative importance of these two properties in controlling galaxy evolution. Methods. We used the zCOSMOS 10k-br...
[This corrects the article DOI: 10.1371/journal.pone.0177902.].
We investigate the interactions of high-redshift galaxy outflows with low-mass virialized clouds of primordial composition. While atomic cooling allows star formation in objects with virial temperatures above 10K, “minihalos” with virial temperatures below this threshold are generally unable to form stars by themselves. However, the large population of high-redshift starburst galaxies may have ...
In this paper we describe the recent advancements made in the IBM i-vector speaker recognition system for conversational speech. In particular, we identify key techniques that contribute to significant improvements in performance of our system, and quantify their contributions. The techniques include: 1) a nearest-neighbor discriminant analysis (NDA) approach that is formulated to alleviate som...
BACKGROUND AND PURPOSE Histotripsy is a noninvasive, pulsed ultrasound technology that produces mechanically homogenized tissue within targeted volumes. Previous work has demonstrated prostatic tissue debulking in a canine model. The aim was to establish safety thresholds by evaluating histologic changes of urinary sphincter, neurovascular bundle (NVB), and rectum after targeted histotripsy tre...
The human genome project has been recently complemented by whole-genome assessment sequence of 32 mammals and 24 nonmammalian vertebrate species suitable for comparative genomic analyses. Here we anticipate a precipitous drop in costs and increase in sequencing efficiency, with concomitant development of improved annotation technology and, therefore, propose to create a collection of tissue and...
Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U.S. Tox21 screening program, the cytotoxicity of ~10K chemicals was interrogated at 0, 8, 16, 24, 32, & 40 hours of exposure in a concentration dependent fashion in two cell lines (HEK293, HepG2) using two multiplexed, real-time assay technologies. One technology measures the metabolic activit...
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