c-Jun is a transcription factor that is involved in various cellular events, including apoptotic cell death. For example, phosphorylation of c-Jun is one of the earliest biochemical changes detected in dying sympathetic neurons after NGF deprivation in vitro. However, currently, it is not known whether a similar molecular event is involved in the developmental programmed cell death (PCD) of neu...

Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription factor c-Jun are important regulators of this cell death program in post-mitotic neurons following survival-factor withdrawal. Our study demonstrate...

Significant increase in JNK, c-Jun, and Cdk5 activities are reported in Alzheimer's disease (AD). Inhibition of c-Jun prevents neuronal cell death in in vivo AD models, highlighting it as a major JNK effector. Both JNK and Cdk5 promote neurodegeneration upon deregulation; however, Cdk5 has not been mechanistically linked to JNK or c-Jun. This study presents the first mechanism showing Cdk5 as a...

this study was aimed at evaluating the effects of planting’s different dates on the trend of leaf area index, dry biomass weight and panicle weight in addition to the yield of rice varieties for one year in the north region of khuzestan, as spilt plots in the form of fully random blocks in three repetitions. main factor was the date of planting at three levels (26 may, 10 jun, 26 jun) and the s...

Aim. Ulcerative colitis (UC) is a refractory gastrointestinal disease. The study aimed to expound the mechanism of Polygonum bistorta (PB) in treating UC by network pharmacology, molecular docking, and experiment verification. Methods. compositions targets PB UC-associated were obtained searching websites literature. potential treatment was predicted protein-protein interaction construction, Ge...

c-jun is the cellular homologue of the recently isolated nuclear onco gene v-jun. This protooncogene encodes the cellular transcription factor AP-1. We have isolated the complementary DNA clone of rat c-jun mRNA. The rat c-jun complementary DNA clone encodes 334 amino acid residues, the sequence of which shows about 98, 96, and 81% homologies with mouse, human, and chicken c-jun products, respe...

(63) Continuation-in-part of application No. 10/645,821, filed on Aug. 20, 2003, and a continuation-in-part of application No. 101175,540, filed on Jun. 18, 2002, and a continuation-in-part of application No.1 01001, 895, filed on Nov. 19, 2001, and a continuation-inpart of application No. 10/001,894, filed on Nov. 19, 2001, now Pat. No. 7,149,957, and a continuationin-part of application No. 1...