نتایج جستجو برای: whole brain radiotherapy

تعداد نتایج: 789268  

2016
Donna H. Murrell Niloufar Zarghami Michael D. Jensen Ann F. Chambers Eugene Wong Paula J. Foster

INTRODUCTION The incidence of brain metastasis due to breast cancer is increasing, and prognosis is poor. Treatment is challenging because the blood-brain barrier (BBB) limits efficacy of systemic therapies. In this work, we develop a clinically relevant whole brain radiotherapy (WBRT) plan to investigate the impact of radiation on brain metastasis development and BBB permeability in a murine m...

2015
Alexander Muacevic John R Adler Javad Rahimian Joseph C Chen Michael J Miller Kenneth Lodin Michael R Girvigian

This report describes the case of a 15-year-old male diagnosed with primary ALK-positive adenocarcinoma of the lung metastatic to the brain. He was treated with surgical resection for a single lesion followed by whole brain radiotherapy and subsequently underwent 10 courses of stereotactic radiosurgery for 47 lesions delivered over a four-year period. Currently, all metastatic lesions in the br...

Journal: :Radiation oncology journal 2016
Taeryool Koo In Ah Kim

Overexpression of human epidermal growth factor receptor 2 (HER2) is found in about 20% of breast cancer patients. With treatment using trastuzumab, an anti-HER2 monoclonal antibody, systemic control is improved. Nonetheless, the incidence of brain metastasis does not be improved, rather seems to be increased in HER2-positive breast cancer. The mainstay treatment for brain metastases is radioth...

2012
Nicolas Coquery Nicolas Pannetier Régine Farion Aurélie Herbette Leire Azurmendi Didier Clarencon Stéphane Bauge Véronique Josserand Claire Rome Jean-Luc Coll Jian-Sheng Sun Emmanuel L. Barbier Marie Dutreix Chantal C. Remy

BACKGROUND Glioma is the most aggressive tumor of the brain and the most efficient treatments are based on radiotherapy. However, tumors are often resistant to radiotherapy due to an enhanced DNA repair activity. Short and stabilized DNA molecules (Dbait) have recently been proposed as an efficient strategy to inhibit DNA repair in tumor. METHODOLOGY/PRINCIPAL FINDINGS The distribution of thr...

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