AIM OF THE STUDY Development of standardized, synergistic, safe and effective traditional herbal formulations with robust scientific evidence can offer faster and more economical alternatives for the treatment of disease. The main objective was to develop a method of preparation of guggulkalpa tablets so that the tablets meet the criteria of efficacy, stability, and safety. MATERIALS AND METH...

The leaves of Carapa guianensis have been used to treat ulcers, skin parasites, and skin problems. The ethanolic extract of C. guianensis leaf was evaluated for its antibacterial and wound healing activity using excision, incision and dead space wound models in rats. The animals were randomly divided into two groups (n = 6) in all the models. In the excision wound model test group animals were ...

Today, tablets are still the most desired form of dosage due to the convenient administration, the chemical and physical stability of the drug in a solid state, and the high production rate of a tabletting machine based on the compaction of powders or granules. Because direct compression vehicles are still in the minority, pharmaceutical powders have to be processed in order to obtain a tailore...

Urea granulation is favored over prilling due to the problems associated with prilling. Tumbling agglomeration technique is employed in pan granulator. Product with wide size range can be produced by playing with only few parameters like binders (water and urea solution), ratio of binders, rpm of pan, granulation time and angle of inclination. Urea granulation is studied at laboratory scale usi...

Binders are important ingredients of solid oral dosage formulations (SODFs). The structure and function of binders play an important role in dosages’ shape and size, delivery, and stability of drug products. The stability of active ingredients depends on external factors, e.g. exposure to heat, oxygen and humidity but also on internal factors, e.g. the impurities such as peroxides, aldehydes, h...

The tablets manufactured by direct compression method using co-processed excipient showed relatively better disintegration time and in vitro drug release, with omission of number of laborious steps as compared to tablets manufactured by conventional wet granulation method. Melt granulation technique is a potential alternative for the development of directly compressible adjuvants. Lactose and m...

The objective of the present investigation was to develop and evaluate sustained release matrix tablets of prochlorperazine maleate employing different types and levels of hydrophilic matrix agents namely hydroxyl propyl methyl cellulose (HPMC), carbopol and combination of these polymers by wet granulation technique. Prior to compression process, the prepared granules were evaluated for its flo...