Pathological excavation of the optic disc in the apparent absence of raised ocular tension was first described by von Graefe (1857), and since then it has aroused interest among ophthalmologists; various names have been given to it and these have reflected ideas about its aetiology. Schnabel (I885) described a cavernous optic atrophy which he believed had resulted from progressive diminution of...

A clinical and pathological atlas. The records of a surgeon in St Vincent, The West Indies. Cecil Cyrus began his studies at Queen's in 1950 and passed his Final MB in 1957. Along the way he worked hard collecting several prizes in his professional examinations, the Symington medal, and a BSc in Anatomy. After a few years he passed his FRCS in England and Edinburgh and gained extensive postgrad...

Recent multicenter studies have clarified the molecular basis underlying the different von Willebrand disease (VWD) types, all of which are caused by the deficiency and/or abnormality of von Willebrand factor (VWF). These studies have suggested a unifying pathophysiologic concept. The diagnosis of VWD, remains difficult because its clinical and laboratory phenotype is very heterogeneous and may...

INTRODUCTION Laboratory diagnosis of von Willebrand disease (VWD) requires determination of both von Willebrand factor (VWF) protein levels and activity. Current VWF activity tests include the ristocetin cofactor assay and the collagen-binding assay (VWF:CB). The goal of this investigation is to characterize a new collagen-binding assay and to determine its effectiveness in identifying VWD. M...

BACKGROUND Nucleotide variations not changing protein sequences are considered silent mutations; accumulating data suggest that they can, however, be important in human diseases. DESIGN AND METHODS We report an altered splicing process induced by a silent substitution (c.7056C>T) in the von Willebrand factor gene in a case of type 1 von Willebrand disease originally classified as lacking von ...

Die Theorie der Wissensräume von DOIGNON/FALMAGNE wird auf ihre Verwertbarkeit als formale Grundlage für ontologiebasierte Kompetenzprofile untersucht. Der Fokus liegt hier zum einen in der Spezifikation von Begriffen, mittels derer die Kompetenzprofile von Akteuren beschrieben werden können. Zum anderen wird von der Konstruktion von Surmise-Systemen eine Erhöhung der Effizienz von Wissensakqui...

Shallowness of the anterior chamber received special attention after the demonstration by von Graefe (1857) that iridectomy could cure acute glaucoma. Bowman (I862) referred to the care required in performing iridectomies on eyes with shallow anterior chambers. Over many years, and by careful dissections of cadaver and enucleated eyes, Priestley Smith (I89I) concluded that the shallow anterior ...

Agile Entwicklungsmethoden versprechen durch die iterative Entwicklung von Anforderungen, Bedürfnisse von Kunden genauer treffen zu können als Ansätze des „klassischen“ Software-Engineering. Ausgehend von drei verschiedenen Pro jekten bei einem deutschen Versicherer berichten wir über unsere Erfahrungen mit der Ermittlung und Entwicklung von Anforderungen. Wir beschreiben das Fördern von Verbin...