This paper reviews our present knowledge of the role of the one-carbon cycle in mood disorder and schizophrenia with particular attention to S-adenosyl methionine (SAM). After an historical introduction the clinical data is first reviewed of the anti-depressant action of SAM, in particular a survey of double blind placebo-controlled trials. Then follows an account of the biochemical parameters ...

Antifolates, folate analogs that inhibit vitamin B9 (folic acid)-using cellular enzymes, have been used over several decades for the treatment of cancer and inflammatory diseases. Cellular uptake of the antifolates in clinical use occurs primarily via widely expressed facilitative membrane transporters. More recently, human folate receptors (FRs), high affinity receptors that transport folate v...

All humans have the same set of genes. Our differences come from the tiny variations in those genes. Those variations influence not only in how you look or behave different to others... But in how your body reacts differently to external factors. Especially how it reacts to the foods you eat. For example, some have great difficulty metabolising caffeine. For others, it could be alcohol ( 1, 2)....

Protoglobin from Methanosarcina acetivorans C2A (MaPgb), a strictly anaerobic methanogenic Archaea, is a dimeric haem-protein whose biological role is still unknown. As other globins, protoglobin can bind O2, CO and NO reversibly in vitro, but it displays specific functional and structural properties within members of the hemoglobin superfamily. CO binding to and dissociation from the haem occu...

AIM To investigate the effect of oral administration of two Bacillus strains on fecal coliforms, Lactobacillus and Bacillus spp. in rat animal model. MATERIALS AND METHODS An in vivo experiment was conducted for 49-day period on 36 adult male albino Wister rats divided equally into to four groups. After 7-day adaptation period, one group (T1) was fed on sterile skim milk along with basal diet...

Neural tissue in developing Xenopus embryos is induced by signals from the dorsal mesoderm. Induction of anterior neural tissue could be mediated by noggin, a secreted polypeptide found in dorsal mesoderm. We show that bFGF, a known mesoderm inducer of blastula staged ectoderm, induces neural tissue from gastrula stage ectoderm. The type of neural tissue induced by bFGF from stage 10.25 ectoder...

Context. Dense molecular cores are studied in order to gain insight into the processes causing clouds to fragment and form stars. In this study we concentrate on a region which is assumed to represent an early stage of clustered star formation in a giant molecular cloud. Aims. The aims of this study are to determine the properties and spatial distribution of dense cores in the relatively quiesc...

In the present study, fluctuations in fatty acids, tocopherols, organic and free sugars content of cardoon blades collected at sixteen harvest dates (samples B1–B16, corresponding to principal growth stages (PGS) between 1 9) were evaluated. A total 26 acids identified, with palmitic (C16:0, 19.9–40.13%), α-linolenic (C18:3n3, 6.39–33.2%), linoleic (C18:2n6c, 9–34.8%) being higher relative abun...