نتایج جستجو برای: vaca c
تعداد نتایج: 1057856 فیلتر نتایج به سال:
Vacuolating cytotoxin A, VacA, is one of the major virulence factors produced by H. pylori and its gene polymorphism might play a major role in strain virulence of H. pylori itself. VacA is produced as a 140 kDa protoxin which undergoes multiple cleavage reactions to give an 88 kDa mature toxin. The 88 kDa protoxin is further cleaved by unknown proteases into 55 kDa C terminal domain (p55) and ...
We describe two subclones of Helicobacter pylori, isolated contemporaneously from a human stomach, which differ markedly in the vacuolating cytotoxin gene, vacA, but whose near identity in sequences outside this locus implies a very recent common origin. The differences are consistent with homologous recombination with DNA from another strain and result in a changed vacA midregion and, importan...
We evaluated a new immunoblot assay (Helicoblot 2.1) for Helicobacter pylori infection and CagA and VacA status by using serum samples from 222 patients. The test accurately detected H. pylori infection and VacA status, but improvements in the interpretation criteria are required before it can be recommended for determination of CagA status.
Helicobacter pylori, a common pathogen that causes chronic gastritis and cancer, has evolved to establish persistent infections in the human stomach. Epidemiological evidence suggests that H. pylori with both highly active vacuolating cytotoxin A (VacA) and cytotoxin-associated gene A (CagA), the major virulence factors, has an advantage in adapting to the host environment. However, the mechani...
Helicobacter pylori has been strongly associated with gastritis, gastric and duodenal ulcers, and it is a risk factor for gastric cancer. Two major virulence factors of H. pylori have been described: the cytotoxin-associated gene product (cagA) and the vacuolating toxin (vacA). Since considerable geographic diversity in the prevalence of H. pylori virulence factors has been reported, the aim of...
AIMS To assess the significance of cagA and vacA subtypes of Helicobacter pylori in relation to inflammation and density of bacterial colonisation in vivo within a dyspeptic UK population. METHODS Dyspeptic patients who were Helicobacter pylori positive had antral samples taken for histology and culture. Gastroduodenal pathology was noted. The grade of bacterial density and inflammation was a...
OBJECTIVE Seroprevalence of H. pylori infection in Iran exceeds 65% of pediatric population. In this study, we intended to find association between the virulence genes (cagA and vacA) and clinical presentations. METHODS H. pylori isolates were achieved from the gastric mucosa of children. In each case, the gastric biopsy specimens were cultured and the organisms identified. Detection of diffe...
چکیده هلیکوباکترپیلوری نقش بسیار مهمی در بروز بیماری های گوارشی مانند التهاب مزمن معده، زخم معده، لنفوم malt و سرطان معده دارد. هدف از این مطالعه بررسی احتمال وجود تفاوت در پروفایل های آللی شناخته شده ژن-بیماری زایvaca هلیکوباکترپیلوری در مناطق جغرافیایی مختلف ایران بویژه نواحی با میزان بروز بالا و پایین سرطان معده و بررسی احتمال وجود گرادیان شمال-جنوب در فراوانی الل های ژن بیماری زایvaca هلی...
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