Understanding the effect of renal transporters on the distribution of drugs, metabolites, and endogenous compounds (e.g., biomarkers for renal toxicity and physiological regulators) are important in safety assessment studies [1]. Drugs (and their metabolites) that preferentially distribute into the kidney may have a greater potential to induce renal toxicity because these compounds may accumula...

background: welding can produce dangerous fumes containing various metals especially carcinogenic ones. occupational exposure to welding fumes is associated with lung cancer. therefore, welders in gas transmission pipelines are known as a high-risk group. this study was designed to determinate the amounts of metals cr, ni, and cd in breathing zone and urine of welders and to assess the possibil...

PURPOSE To determine the expression of prostate cancer antigen 3 (PCA3) gene in peripheral blood and urine sediments from patients with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and normal subjects. MATERIALS AND METHODS A total number of 48 patients [24 with biopsy proven prostate cancer (PCa) and 24 with benign prostate hyperplasia (BPH)] were studied. Twenty-four healthy...

BACKGROUND The present study is an evaluation of a self-collected urine dip (SCUD) swab as an alternative sampling method for the detection of Chlamydia trachomatis (CT) in urine samples that conforms to postal service regulations in Australia. METHODS Sixty urine samples, previously identified as CT positive were used to prepare SCUD swabs in vitro. In addition, replicate SCUD swabs were pre...

QUESTIONS Is the novel in-vitro diagnostic device U-Test(®) reliable and secure for urine collection in diaper-wearing children and simultaneous evaluation of the urine collected for the presence of leucocytes and nitrite? METHODS The qualitative and functional performance of U-Test(®) was evaluated in a multicentre prospective clinical trial. The diagnostic performance of the novel in-vitro ...

conclusions vancomycin nephrotoxicity is common but usually reversible and has readily manageable adverse effect. urine kim-1 was not more accurate than serum or urine creatinine in detecting vancomycin nephrotoxicity in our study population. results thirteen out of the 52 recruited patients (25%) developed nephrotoxicity, with a mean ± standard deviation onset of 11.46 ± 7.56 days. furosemide ...

leptospirosis is a zoonosis of worldwide distribution, caused by leptospira interrogans and is considered as an emerging global public health problem. transmission usually results from direct or indirect exposure to the urine or other body fluids of leptospiruric animals which may become a source of infection for human or other animals. having a humid climate with plenty of annual rainfall, gui...