September 4, 2008; 1:00 p.m. (EST): Earlier this year several batches of heparins were initially recalled due to the increased prevalence of adverse reactions and deaths. Initially the US FDA recalled specific batches of heparin resulting in a total recall of Baxter’s unfractionated heparin. Since then Baxter has not reintroduced this product despite the fact that it had 50% of the total market...

Venous thromboembolism (VTE) is a prevalent and serious condition, which requires anticoagulation treatment for prolonged time duration. The use of unfractionated heparin administered intravenously or subcutaneously for acute management of VTE has been studied with favourable clinical results. Most physicians use activated partial thromboplastin time to monitor the treatment effect, in an effor...

1 Suh JS, Aster RH, Visentin GP. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis recognize different epitopes on heparin: platelet factor 4. Blood 1998; 91:916–922 2 Jang IK, Hursting MJ. When heparins promote thrombosis: review of heparin-induced thrombocytopenia. Circulation 2005; 11:2671–2683 3 Amiral J, Peynaud-Debayle E, Wolf M, et al. Generation of antibodies to ...

The objective of this study was to characterize the heparin-binding properties of a protein secreted by mouse myeloma cells. The characterization was performed using clinical assays, such as heparin activity assays and heparin-induced thrombocytopenia (HIT) platelet activation assays. The tests were performed in the presence of heparin, low-molecular-weight heparins (LMWH), or heparinoids and e...

Essa revisão possui como objetivo realizar uma comparação de benefícios entre a eficácia da HNF e Enoxaparina na diminuição mortalidade em pacientes adultos com risco aumentado ou vítimas TEP. A busca dos artigos foi feita utilizando os termos “Unfractionated heparin”, “Low-Molecular-Weight-heparin” “Pulmonary Embolism” além do operador booleano “and”, por meio ampla literatura Library Cochrane...