Aims of Study It is well known that the activation of the sympathetic nervous system contributes to urine storage by relaxing the detrusor via activation of beta-adrenoceptors (beta-ARs). It has been demonstrated that the relaxation of human detrusor, including the neurogenic detrusor, is mediated mainly via beta3-ARs [1-3]. However, the beta3-AR agonists previously used, such as BRL37344A, CL3...

Cytochrome P450 2D6 (CYP2D6), which has a large number of genetic polymorphisms, is involved in the metabolism of a wide range of substrates. Dextromethorphan (DM) is a well-known probe drug for CYP2D6 and metabolic ratio (MR) is often used to measure the enzyme activity in vivo. Using the literature values of DM MR, we estimated the inter-individual variability of CYP2D6 hepatic intrinsic clea...