We compare a new ultrafiltration technique, involving a unique Millipore membrane, with the classical method of equilibrium dialysis for determining the fraction of thiopental not bound to serum proteins. This fraction, as determined by equilibrium dialysis at 37 degrees C, ranged between 12 and 16% for total concentrations at 50 microgram/L to 10 mg/L of serum. In contrast, ultrafiltration at ...

laryngeal mask is a supraglothic instrument for ventilation of patients who are under anesthesia. insertion of laryngeal mask requires maintaining sufficient depth of anesthesia to avoid airway reflex (gagging, coughing and spasms). the present study investigated two techniques of anesthesia with propofol-atracurium and thiopental-atracurium to facilitate insertion of the laryngeal mask, term o...

rabbits are widely used as laboratory animals for experimental surgery. anesthesia of rabbits may present complications unless the method is easy to apply and safe to use. in present study, effects of different dosages of vitamin c on thiopental sodium induced anesthesia in 25 male new zealand white rabbits were studied. in the animals that had not received vitamin c treatment before thiopental...

background:   objective: this study aimed at investigating the side effects and hemodynamic effects of using thiopental sodium and propofal as well as effects of these drugs on pregnancy outcome in art cycles.   materials and methods: in this double blinded) randomized controlled trial, 90 woman candidate for art were randomly divided into two groups. 47 patients received propofol (2.5 mg/kg) a...

both midazolam and thiopental sodium are being used as induction agents and for maintenance of anesthesia. in contrast to other benzodiazepines such as diazepam, midazolam has a rapid onset of action and fast distribution and causes few cardiovascular or respiratory effects. being water soluble, midazolam is also associated with a low incidence of venous irritation. the purpose of this study wa...

We describe a system for monitoring and controlling i.v. anaesthesia in rats using burst suppression ratio (BSR) detection in the extradural EEG. After bolus injection, peak BSR values of 95% were achieved with propofol 8 mg kg-1, etomidate 3.5 mg kg-1 and alphaxalone 4.5 mg kg-1. Thiopental 32 mg kg-1 produced a peak BSR of 70% (larger doses were not tolerated). Recovery was fastest with propo...

1 Zand F, Hadavi SMR, Chohedri A, Sabetian P. Survey on the adequacy of depth of anaesthesia with bispectral index and isolated forearm technique in elective Caesarean section under general anaesthesia with sevoflurane. Br J Anaesth 2014; 112: 871–8 2 Tunstall ME. The reduction of amnesic wakefulness during caesarean section. Anaesthesia 1979; 34: 316–9 3 Russell IF. The ability of bispectral i...

Propofol (Diprivan) in a new formulation, a short-acting intravenous anesthetic, was used as an induction agent for short urological procedures. Forty unpremedicated patients were treated with either propofol or thiopental in a randomized study. The onset of anesthesia and duration of apneic period were prolonged and the decrease in systolic blood pressure was more profound in the propofol grou...

A number of papers have been presented in support of the concept that epinephrine potentiates barbiturate anesthesia in experimental animals (1-3). Recently, Mazel et al. (4) reported that epinephrine increased the brain level of barbital above controls and suggested that epinephrine may affect the permeability of the blood-brain barrier as well as other barriers. However, mechanism of the pote...

We have assessed, by intravital microscopy in rats, the effects of different anaesthetics on diaphragmatic arteriolar diameter. Rats were anaesthetized with etomidate, propofol or thiopental (groups E, P and T, respectively) and the diameters of the arterioles were measured sequentially at baseline and after topical application of either mefenamic acid (MA, 20 mumol litre-1) or N omega-nitro-L-...