Two dinuclear copper(II) thioether-oxime complexes ([Cu(DtdoH)]2(ClO4)2 and [Cu(DtudH)]2(ClO4)2 Æ 2CH3OH) have been synthesized. [Cu(DtdoH)]2(ClO4)2 reacted with excess BF3 Æ OEt2 to yield [Cu(Thyclops)]ClO4, a BF2 þ-macrocyclized di-oxime. [Cu(DtdoH)]2(ClO4)2 and [Cu(DtudH)]2(ClO4)2 Æ 2CH3OH are the first representatives of copper(II) thioether oximes which exhibit the classical out-of-plane o...

Petroleum is a complex mixture of lipophilic chemicals, some of which are likely to be substrates for the microsomal mixed function oxygenases. Petroleum retailers, by virtue of their occupational exposure potential, are a group likely to receive relatively heavy exposure to petroleum products in comparison with the general public. Urinary thioether output may provide a simple, non-invasive tec...

Cytochrome P450 (P450) and flavin-containing monooxygenase (FMO) enzymes are major catalysts involved in the metabolism of xenobiotics. The sulfoxidation of the thioether pesticides, phorate, disulfoton, sulprofos, and methiocarb, was investigated. Using pooled human liver microsomes (HLMs), thioether compounds displayed similar affinities; however, phorate and disulfoton displayed higher intri...

When CnrX, the periplasmic sensor protein in the CnrYXH transmembrane signal transduction complex of Cupriavidus metallidurans CH34, binds the cognate metal ions Ni(II) or Co(II), the ECF-type sigma factor CnrH is made available in the cytoplasm for the RNA-polymerase to initiate transcription at the cnrYp and cnrCp promoters. Ni(II) or Co(II) are sensed by a metal-binding site with a N3O2S coo...

macrocyclic heterobinuclear zn(ii)–cu(ii) complexes with phenol based dicompartmental ligands possessing contiguous hexa- and penta-coordination sites were prepared by a stepwise procedure. the ligands include similar n4o2 and dissimilar n(imine)3o2 and n(amine)3o2 coordination sites sharing two phenolic oxygen atoms. the six-coordination site comprises two pyridyl pendant arms on the amine nit...

The selective and effective synthesis of organic carbonates under mild conditions, starting from carbon dioxide and oxiranes, catalyzed by metal complexes is currently a focus of interest for both industrial and academic researchers. We recently developed a novel thioether-triphenolate iron(III) catalyst (Ct-BU) that has proven to be highly active for the coupling of CO2 with epoxides, resultin...

The mononuclear macrocyclic Pd(II) complex cis-[PdCl2([9]aneS3)] ([9]aneS3 = 1,4,7-trithiacyclo-nonane) converts at 44 kbar into an intensely coloured chain polymer exhibiting distorted octahedral coordination at the metal centre and an unprecedented [1233] conformation for the thioether ligand. The evolution of an intramolecular axial sulfur-metal interaction and an intermolecular equatorial s...

In this paper we explore cisplatin interactions with sulfur-containing amino acids in a polarizable continuum model. Two cisplatin hydrated complexes were considered as reactants (chloro complex, cis-[Pt(NH3)2Cl(H2O)]+; hydroxo complex, cis-[Pt(NH3)2(OH)(H2O)]+). We considered the following reaction mechanism: first step, substitution of the aqua ligand by amino acid; second step, dissociative ...