OBJECTIVE To investigate puberty in a group of thalassemic patients with delayed or arrested pubertal development and to compare the effects of hormonal and L-carnitine therapy on puberty in those patients. PATIENTS Thirty-two -thalassemic patients with arrested or failure of puberty were enrolled for 1 year in this study. METHOD Clinical pubertal assessment and laboratory investigations we...

BACKGROUND Iron overload in patients with thalassemia is a common feature which requires continuous chelation therapy and monitoring. Serum ferritin determination is widely accepted as a simple method for following iron load in patients with primary hemochromatosis; however, several reports on thalassemic patients emphasize that ferritinemia is not accurate and that other methods such as direct...

Post transfusion purpura (PTP) is a rare condition and only 200 cases have been reported so far. It is commonly seen in women, with a preponderance in the sixth and seventh decade. Majority of these cases have been observed in whites and the condition is rare among Asian patients(l). It has not yet been reported in children(2). PTP is characterized by the development of thrombocytopenia associa...

Background: Thalassemia constitutes a major public health problem causing a significant burden on children and their families. Zinc deficiency plays an important role in many thalassemia-related complications like growth retardation, hypogonadism and delayed puberty which are frequently noted in adolescent age. Although zinc is supplemented to thalassemic patients visiting Day Care Center, Yang...

results mean ± standard deviation (sd) of plasma zinc levels was determined as 0.78 ± 0.22 mg/l. also zinc level was 0.76 ± 0.19 mg/l and 0.80 ± 0.24 mg/l in thalassemic and non thalassemic patients, respectively. t-test analysis showed that there is no significant difference between these two groups regarding plasma zinc level (p = 0.235). conclusions it is concluded that zinc level of studied...

introduction: transfusion-transmitted infections (tti) continue to be a major challenge for blood transfusion organizations in the world and multi- transfused patients (mtps) are at higher risk of infection. htlv-1 is a retrovirus that easily transmitted via blood cell products. the aim of this study is determine the seroprevalence of htlv-1 in major thalassemic patients from kermanshah provinc...

The aim of this study was to examine the feasibility of using an economic and practical method in order to perform non-invasive prenatal testing of thalassemia as a sing gene disorder.Sixteen (16) pregnant mothers in the 11th week of pregnancy who were referred for prenatal diagnosis of thalassemia were selected. The parents had one of IVSII-1, IVSI-5 or FR codon 8/9 mutations. Enrichment of cf...

Abstract Background β−Thalassemic children have oxidative stress and antioxidant deficiency even without iron overload status. In these patients, tissue damage due to oxidative stress may be occurred. Also, it seems that thalassemic patients have higher levels of ALT, AST therefore, the main aim of the present study was to determine the benefits of vitamin E as an antioxidant supplements in β...