AML patients are reported to have impairments of immune cells which contribute to leukemia progression. Tumor-derived exosomes (TEX) have recently emerged as carriers of the molecular and genetic cargo with potent immunosuppressive properties. We showed that plasma of newly-diagnosed AML patients prior to any therapy contained high levels of exosomal proteins relative to those in plasma of norm...

Methods Single-blind clinical trial. The tissue samples obtained from patients PAS, hematoxylin and eosin, E-Cadherin, CTGF, Tunnel, and staining for TGF-b1 is applied and evaluated by light microscopy. Additionally, we have analyzed both TGFB1 level and mRNA expression analysis in plasma and tissue samples from patients. A total of 15 patients were enrolled in the study. These patients, who we...

20-Hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 arachidonic acid metabolite, has been shown to modulate the growth of vascular smooth muscle cells (VSMCs). We asked whether 20-HETE modulates the proliferation of R22D cells, a clonal VSMC from neonatal rats, by releasing transforming growth factor-b (TGF-b). Incubation of R22D cells with 20-HETE for 24 h attenuated [H]thymidine inco...

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population that primarily suppress T lymphocytes in healthy pregnancies and pathologies. MDSCs one of the key regulators immune responses. Finding ways to control them is important for treatment cancer, autoimmune diseases, miscarriage, post-transplant complications. The mechanisms suppression by MDSC are: expression CD73, ADAM17...

BACKGROUND Phyllanthus niruri L. is a well-known hepatoprotective and antiviral medicinal herb. Recently, we identified Corilagin as a major active component with anti-tumor activity in this herbal medicine. Corilagin is a member of the tannin family that has been discovered in many medicinal plants and has been used as an anti-inflammatory agent. However, there have been few reports of the ant...

In this study, we have showed that GCNT2, a gene-encoding glucosaminyl (N-acetyl) transferase 2, I-branching enzyme, is overexpressed in highly metastatic breast cancer cell lines of human and mouse origin and basal-like breast tumor samples. GCNT2 expression is also significantly correlated to the metastatic phenotype in breast tumor samples. Functional studies showed that ectopic expression o...

CD105, a receptor for TGF-b1 and -b-3 modulates TGF-b signaling by interacting with TGF-bRI and/or II. It is now emerging as a prime vascular target of antiangiogenetic cancer therapy. In the present study, we investigate the efficacy of CD105 in colorectal cancer models. We found decreases in tumor size and in the number of metastatic foci to lung in a xenograft cancer model in scid mouse that...