Diabetes Mellitus type 2 (T2DM) is the most common form of diabetes [WHO (2008)]. More than 29 million people in the United States are affected by T2DM and another 86 million are in a state of prediabetes, a condition that exhibits high risk to progress into diabetes [NIH (2014)]. Many T2DM cases can be prevented or avoided by improved awareness and lifestyle adjustments [NIH (2014)]. Our proje...

BACKGROUND We previously showed that unesterified-cholesterol transfer to high-density lipoprotein (HDL), a crucial step in cholesterol esterification and role in reverse cholesterol transport, was diminished in non-diabetic patients with coronary artery disease (CAD). The aim was to investigate whether, in patients with type 2 diabetes mellitus (T2DM), the occurrence of CAD was also associated...

BACKGROUND Risk of type 2 diabetes mellitus (T2DM) is increased in metabolically obese but normal-weight people. However, we have limited knowledge of how to prevent T2DM in normal-weight people. We aimed to evaluate the association between triglyceride glucose (TyG) index and incident T2DM among normal-weight people in rural China. METHODS We included data from 5706 people with normal body m...

BACKGROUND Gastrointestinal symptoms are common in patients with type 2 diabetes mellitus (T2DM). The prevalence of gastroesophageal reflux disease (GERD) in Korea appears to be increasing. Some studies have shown that T2DM is a risk factor for symptomatic GERD. However, this possibility is still debated, and the pathogenesis of GERD in T2DM is not yet fully understood. The aim of this study wa...

Backgrounds: Generally, a prevalence of obesity increasing constantly represents one of major health care and social problems. Many researchers indicate that obesity has a risk factor for type 2 diabetes mellitus (T2DM), but some persons believe that obesity may occur T2DM. GLP-1 and GIP as incretin hormone are secreted in response to ingestion of nutrients. In the circulation, they are rapidly...

BACKGROUND Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrome. H. pylori infection and type 2 diabetes mellitus (T2DM) are associated with oxidative stress, this cross-relation between H. pylori induced infection in T2DM and oxidative damage is still debated. Th...

Tuberculosis (TB) remains an eminent global burden with one third of the world's population latently infected with Mycobacterium tuberculosis (M. tb). Individuals with compromised immune systems are especially vulnerable to M. tb infection. In fact, individuals with Type 2 Diabetes Mellitus (T2DM) are two to three times more susceptible to TB than those without T2DM. In this study, we report th...

BACKGROUND Exercise training programs have emerged as a useful therapeutic regimen for the management of type 2 diabetes mellitus (T2DM). Majority of the Western studies highlighted the effective role of exercise in T2DM. Therefore, the main aim was to focus on the extent, type of exercise and its clinical significance in T2DM in order to educate the clinicians from developing countries, especi...