Heart failure with preserved ejection fraction (HFpEF) continues to be a challenging form of heart failure - one in which no therapy has yet been proven to improve outcome. Aldosterone antagonists have previously been shown to improve survival in a wide spectrum of patients with heart failure with reduced ejection fraction (HFrEF), and more recently, small trials suggested that they might have ...

Recent technological advances allow precise radiation delivery to tumor targets. As opposed to more conventional radiotherapy-where multiple small fractions are given-in some cases, the preferred course of treatment may involve only a few (or even one) large dose(s) per fraction. Under these conditions, the choice of appropriate radiobiological model complicates the tasks of predicting radiothe...

OBJECTIVE To investigate the role of growth/adhesion-regulatory lectins in the prognosis of the stage II non-small cell lung carcinomas (NSCLCs) via quantitative lectinhistochemical examinations and measurement of microvascularization of the tumour. METHODS In 94 radically operated lung cancer patients, stage II NSCLC was confirmed histologically (T1N1: 6, T2N1: 66, T3N0: 22). Immunohistochem...

BACKGROUND The objective of this study was to identify the impact of diabetes and related comorbidities, namely chronic renal failure, peripheral vascular disease, and low ejection fraction (<35%), on long-term survival of patients undergoing coronary artery bypass graft surgery. METHODS AND RESULTS A unicenter study was conducted on 9125 survivors of isolated coronary artery bypass graft sur...

conclusion the cv value correlated more closely with low lvef and more accurately indicated an enlarged heart than ca or ctr. this may be due to the fact that an anteroposterior measurement of heart size is included in the former but not the latter two measurements. these study results may help quantify left heart enlargement with greater accuracy than may be obtained from standard cxr. backgro...

in this article cuo/water nanofluid was synthesized by using polyvinylpyrolidone (pvp) as the dispersant.  thenanofluid stability period and the heat transfer enhancement were determinedby measuring the thermal conductivities. to study the nano-fluid stability, zeta (ζ) potential, and absorbency were measured under different ph values and pvp surfactant concentrations; also thermal conductivity...

A typical tumor induction experiment consists of the application of a single treatment to a number of animals (N) which are then observed for a certain time, the follow-up period. At the end of this period, at time T, a fraction b = n / N will have responded with tumor after varying tumor appearance time h( i = 1, !~ . . . . n). Frequently there is also a fraction d = n ' / N "dead without tumo...

Introduction: Survival modeling is a very important tool to detect risk factors and provide a basis for health care planning. However, cancer data may have properties leading to distorted results with routine methods. Therefore, this study aimed to cover specific factors (competing risk, cure fraction and heterogeneity) with a real dataset of Iranian breast cancer patients using a competing ris...

the relationship between the way in which normal hemopoietic stem cells respond to irradiation alone or in the presence of bleomycin sulfate (blm-s) and actinomycin 0 (act-d) was investigated. single doses of blm-s at 0.3 mg/kg and act-o at 0.10 mg/kg body weight were injected intravenously 1-6 hours prior to whole body irradiation and treatment was repeated twice more with time intervals. when...

BACKGROUND AND OBJECTIVES Esophageal cancer is a major cause of mortality and morbidity in the Caspian littoral north-eastern part of Iran. The aim of this study was to calculate cure function as well as to identify the factors that are related to this function among patients with esophageal cancer in this geographical area. METHODS Three hundred fifty nine cases of esophageal cancer register...