W e read with interest the report on corticobasal syndrome by Rajagopal et al (1). At times, this neurodegenerative disorder may lead to vertical gaze palsy. We evaluated a patient with valproate toxicity and hyperammonemia and reversible vertical gaze palsy. A 56-year-old man presented with progressive unsteadiness, drowsiness, and cognitive decline for the past 6 months. Twenty-five years pre...

B. P., female, aged 14 years, admitted to the Worcester Eye Hospital on February 28, 1952, for operation to overcome congenital inaction of the right external rectus. There was no movement of the right eye beyond the mid-line when looking right but 5A right hyperphoria was produced by the attempt. In the primary position there was no hyperphoria. Spectacles were worn for slight convergent strab...

We investigated the immediate and long-term changes in static eye alignment with acute superior oblique palsy (SOP) in the monkey. When the paretic eye was patched immediately after the lesion for 6-9 days, vertical alignment slowly improved. When the patch was removed and binocular viewing was allowed, alignment slowly worsened. In contrast when a monkey was not patched immediately after the l...

We present a case of an 18 year old white male with Burkitt's lymphoma who was operated on for hydrocephalus and subsequently referred for evaluation of new onset diplopia. On examination, his visual acuity (VA) was 20/20 in both eyes with a right superior oblique palsy. His pupillary reaction to light was intact while on near gaze there was no constriction of the pupils, bilaterally. The other...

In this chapter we describe a variety of rare but clinically identifiable ocular motor syndromes, including ocular neuromyotonia, superior oblique myokymia, ocular motor synkinesis, third nerve palsy with cyclic spasms, and paroxysmal manifestations of multiple sclerosis. These syndromes share many characteristics. They result from neurogenic hyperactivity, causing episodic spasms of one or sev...