نتایج جستجو برای: subcutaneous human preadipocyte

تعداد نتایج: 1671344  

2017
Tao Zhang Xiangqian Zhang Kunpeng Han Genxi Zhang Jinyu Wang Kaizhou Xie Qian Xue Xiaomei Fan

Long noncoding RNAs (lncRNAs) regulate metabolic tissue development and function, including adipogenesis. However, little is known about the function and profile of lncRNAs in intramuscular preadipocyte differentiation in chicken. Here, we identified lncRNAs in chicken intramuscular preadipocytes at different differentiation stages using RNA sequencing. A total of 1,311,382,604 clean reads and ...

2016
Min-Kyung Jang Sunwoo Lee Myeong Ho Jung

In this study, we performed high throughput RNA sequencing at the preadipocyte (D0) and differentiated adipocyte (D7) stages of primary brown preadipocyte differentiation in order to characterize the transcriptional events regulating differentiation and function. Compared to the preadipocyte stage (D0), 6,668 genes were identified as differentially expressed genes (DEGs) with a fold change of ≥...

2017
Wei Wang Tianmu Zhang Chunyan Wu Shanshan Wang Yuxiang Wang Hui Li Ning Wang

The chicken is an important agricultural animal and model for developmental biology, immunology and virology. Excess fat accumulation continues to be a serious problem for the chicken industry. However, chicken adipogenesis and obesity have not been well investigated, because no chicken preadipocyte cell lines have been generated thus far. Here, we successfully generated two immortalized chicke...

2014
Zhouchun Shang Lin Guo Ning Wang Hui Shi Yuxiang Wang Hui Li

In addition to providing energy and constituting cell membrane, fatty acids also play an important role in adipocyte differentiation and lipid metabolism. As an important member of monounsaturated fatty acids, oleate, together with other components, is widely used to induce chicken preadipocyte differentiation. However, it is not clear whether oleate alone can induce chicken preadipocyte differ...

Journal: :The Journal of clinical investigation 2002
Takafumi Yokota C S Reddy Meka Kay L Medina Hideya Igarashi Phillip C Comp Masahiko Takahashi Makoto Nishida Kenji Oritani Jun-Ichiro Miyagawa Tohru Funahashi Yoshiaki Tomiyama Yuji Matsuzawa Paul W Kincade

Adiponectin, an adipocyte-derived hormone, was recently shown to have potential therapeutic applications in diabetes and obesity because of its influence on glucose and lipid metabolism. We found that brown fat in normal human bone marrow contains this protein and used marrow-derived preadipocyte lines and long-term cultures to explore potential roles in hematopoiesis. Recombinant adiponectin b...

Journal: :Physiological research 2014
J Ždychová S Čejková I Králová Lesná A Králová J Malušková L Janoušek L Kazdová

The abnormal proliferation of vascular smooth muscle cells (VSMC) is thought to play a role in the pathogenesis of atherosclerosis. Adipocytes produce several bioactive paracrine substances that can affect the growth and migration of VSMCs. Our study focuses on the direct effect of the bioactive substances in conditioned media (CM) that was obtained by incubation with primary adipocyte-derived ...

Journal: :American journal of physiology. Cell physiology 2002
Andrea Bell Annemarie Gagnon Patti Dods Denise Papineau Mario Tiberi Alexander Sorisky

Thyroid-stimulating hormone (TSH) action in adipose tissue remains largely unknown. Our previous work indicates that human preadipocytes express functional TSH receptor (TSHR) protein, demonstrated by TSH activation of p70 S6 kinase (p70 S6K). We have now studied murine 3T3-L1 preadipocytes to further characterize TSH signaling and cellular action. Western blot analysis of 3T3-L1 preadipocyte l...

2012
Jing Yang Jinhua Yin Hongfei Gao Linxin Xu Yan Wang Lu Xu Ming Li

Berberine is known to inhibit the differentiation of 3T3-L1 cells in vitro, improve glycemic control, and attenuate dyslipidemia in clinical study. The aim of this study was to investigate the effects of berberine on preadipocytes isolated from human omental fat and in metabolic syndrome patients treated with berberine for 3 months. We have shown that treatment with 10 μM berberine resulted in ...

2015
Ângela Moreira Sofia S. Pereira Madalena Costa Tiago Morais Ana Pinto Rúben Fernandes Mariana P. Monteiro

Obesity has been associated with increased incidence and risk of mortality of prostate cancer. One of the proposed mechanisms underlying this risk association is the change in adipokines expression that could promote the development and progression of the prostate tumor cells. The main goal of this study was to evaluate the effect of preadipocyte and adipocyte secretome in the proliferation, mi...

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