Members of the Slug/Snail family of transcription factors are thought to drive epithelial-mesenchymal-transition (EMT) in preneoplastic epithelial cells, thereby contributing to malignant transformation. One mediator in the EMT of pancreatic ductal adenocarcinoma (PDAC) cells and a potential target gene of Slug is the cellular adhesion molecule L1CAM. Using the human pancreatic ductal epithelia...

The transcriptional repressors Snail and Slug are situated at the core of several signaling pathways proposed to mediate epithelial to mesenchymal transition or EMT, which has been implicated in tumor metastasis. EMT involves an alteration from an organized, epithelial cell structure to a mesenchymal, invasive and migratory phenotype. In order to obtain a global view of the impact of Snail and ...

The Snail family of zinc-finger transcription factors are evolutionarily conserved proteins that control processes requiring cell movement. Specifically, they regulate epithelial-to-mesenchymal transitions (EMT) where an epithelial cell severs intercellular junctions, degrades basement membrane and becomes a migratory, mesenchymal-like cell. Interestingly, Slug expression has been observed in a...

Recent gas flux measurements have shown that Strombolian explosions are often followed by periods of elevated flux, or "gas codas," with durations of order a minute. Here we present UV camera data from 200 events recorded at Stromboli volcano to constrain the nature of these codas for the first time, providing estimates for combined explosion plus coda SO2 masses of ≈18-225 kg. Numerical simula...

Electrical Capacitance Tomography (ECT) can be used to measure concentration and velocity distributions in two-phase flows. ECT is non-intrusive, and the reconstruction of the concentration and velocity distribution can be undertaken in real time and over an arbitrary number of zones in the flow cross-section. The concept of a ‘virtual instrument’ is introduced where zones of the image can be s...

Abstract. In this work we show existence of global weak solutions for a two-phase gas-liquid model where the gas phase is represented by a general isothermal pressure law whereas the liquid is assumed to be incompressible. To make the model relevant for pipe and well-flow applications we have included external forces in the momentum equation representing respectively wall friction forces and gr...

The Dictyostelium discoideum asexual fruiting body consists of spores, stalk and basal disk cells. Recently, a fourth cell class has been proposed. It has been suggested that these cells originate from anterior-like cells that remain undifferentiated. Anterior-like cells are randomly distributed among prespore cells in the posterior part of the slug. Here monoclonal antibodies that recognize th...

Flows in small size channels have been studied for a long time over multidisciplinary field such as chemistry, biology and medical through the various topics. Recently, the attempts of electricity generation from the small flows as a new area for energy harvesting in microfluidics have been reported. Here, we propose for the first time a new fluidic electricity generator (FEG) by modulating the...

Slug (Snail2) plays critical roles in regulating the epithelial-mesenchymal transition (EMT) programs operative during development and disease. However, the means by which Slug activity is controlled remain unclear. Herein we identify an unrecognized canonical Wnt/GSK3β/β-Trcp1 axis that controls Slug activity. In the absence of Wnt signaling, Slug is phosphorylated by GSK3β and subsequently un...

PURPOSE Carcinoma progression is linked to a partially dedifferentiated epithelial cell phenotype. As previously suggested, this regulation could involve transcription factors, Snail and Slug, known to promote epithelial-mesenchymal transitions during development. Here, we investigate the role of Snail and Slug in human breast cancer progression. EXPERIMENTAL DESIGN We analyzed Snail, Slug, a...