This paper investigates the light-driven migration of the multi-cellular microorganism Dictyostelium discoideum as a potential bio-actuation mechanism in microsystems. As a platform for slug migration we use microscale confinements, which consist of intersecting microchannels fabricated from solidified agar-water solution. The agar surface provides necessary moisture to the slugs during the exp...

Slug test data obtained from tests performed in an unconfined aquifer are commonly analyzed by graphical or numerical approaches to determine the aquifer parameters. This paper derives three fourth-degree polynomials to represent the relationship between Bouwer and Rice's coefficients and the ratio of the screen length to the radius of the gravel envelope. A numerical approach using the nonline...

Lung cancer is the leading cause of cancer death worldwide. Cancer metastasis and resistance to treatment (including radiotherapy, chemotherapy and targeted therapy) are two major causes for the poor survival of lung cancer patients. Epithelial-mesenchymal transition (EMT) is involved in cancer cell invasion, resistance to apoptosis and stem cell features. The process of EMT is controlled by a ...

A microchannel reactor improves the overall mass and heat transfer as compared with a conventional reactor. This is attributed to creation of high area-to-volume ratio enhanced mixing due presence vortices inside slug. In this paper, mass-transfer performance was studied using cross-junction microchannel. Subsequently, computational fluid dynamic (CFD) method used observe oil concentration cont...

When shaken in a glucose-albumin-cAMP medium, dissociated aggregative cells formed small clumps, in which both prespore and prestalk cells differentiated in essentially the same proportions as in a slug. Immunocytochemical staining of sections of such clumps revealed that the two types of cells showed no particular pattern of distribution, unlike the two-zoned prestalk-prespore pattern as obser...

The epithelial-mesenchymal transition (EMT), considered essential for metastatic cancer, has been a focus of much research, but important questions remain. Here, we show that silencing or removing H2A.X, a histone H2A variant involved in cellular DNA repair and robust growth, induces mesenchymal-like characteristics including activation of EMT transcription factors, Slug and ZEB1, in HCT116 hum...

The aim of this study is to clarify whether epithelial-mesenchymal transition (EMT) is involved in the pathogenesis and development of keratocystic odontogenic tumor (KCOT). The expression levels of EMT-related proteins and genes in normal oral mucosa (OM), radicular cyst (RC), and KCOT were determined and compared by real-time quantitative PCR and immunohistochemistry. Our data showed that the...

Abstract We performed a characterization of the bubbly and slug flow regimes in minichannels in conditions relevant to microgravity. Two-phase flows were generated on ground by means of a T-junction device (1 mm i.d.), whose operation is independent to changes in gravity level [1]. Air and water were injected at several superficial velocities ranging from 0 up to 2 m/s. The generation and detac...

In this paper, numerical investigation of upward two phase flow of air-water has been studied. Different conditions of flow regimes including annular, wispy annular, slug, churn and bubbly are simulated based on Hewitt and Roberts map, and a good agreement between the experimental data of the map and the numerical simulation has been observed. Accordingly, a proper CFD model in CFD software of ...

A semianalytical solution is presented to a mathematical model describing the flow of groundwater inresponse to a slug test in a confined or unconfined porous formation. The model incorporates the effects of partial penetration, anisotropy, finiteradius well skins, and upper and lower boundaries of either a constant-head or an impermeable form. This model is employed to investigate the error th...