نتایج جستجو برای: s retinoic acid

تعداد نتایج: 1400096  

Journal: :Investigative ophthalmology & visual science 2006
Tongalp H Tezel Lijun Geng Henry J Kaplan Lucian V Del Priore

PURPOSE To determine whether retinoids are capable of inducing vascular endothelial cell apoptosis and whether the presence of an intact RPE monolayer can block retinoid-induced vascular endothelial cell death. METHODS Confluent fetal bovine aortic endothelial (FBAE) cells were incubated with various concentrations of all-trans or 9-cis retinoic acid (an analogue of 11-cis retinoic acid). Apo...

Journal: :Experimental eye research 2000
J R Mertz J Wallman

Research over the past two decades has shown that the growth of young eyes is guided by vision. If near- or far-sightedness is artificially imposed by spectacle lenses, eyes of primates and chicks compensate by changing their rate of elongation, thereby growing back to the pre-lens optical condition. Little is known about what chemical signals might mediate between visual effects on the retina ...

2014
Kristin M. Obrochta Maureen A. Kane Joseph L. Napoli

The relationship between dietary vitamin A and all-trans-retinoic acid levels in serum and tissues had not been quantified. We determined the impact of dietary vitamin A on retinoid levels in serum, liver, kidney, testis, and epididymal white adipose of five mouse strains: AKR/J; BALB/cByJ; C3H/HeJ; C57BL/6J; 129S1/SvImJ. Retinoids were quantified in mice fed copious vitamin A (lab chow, ≥20 IU...

Journal: :Cancer research 1995
D R Shalinsky E D Bischoff M L Gregory M M Gottardis J S Hayes W W Lamph R A Heyman M A Shirley T A Cooke P J Davies

Retinoids are promising agents for therapy of squamous cancers. In vitro, retinoids decrease expression of differentiation markers in head and neck squamous carcinoma cells. Little information is available on effects of retinoids on head and neck squamous carcinoma cell xenograft growth in vivo. To address this issue, head and neck squamous carcinoma cells (line 1483) were established as xenogr...

2006
Victoria L. Stevens Nancy E. Owens Elliott F. Winton Joseph M. Kinkade Alfred H. Merrill

The human cell line HL-60 was used to investigate the role of protein kinase C in the regulation of retinole acid-induced maturation of promyelocytic leukemia cells by growth and differentiation factors found in serum. Cells grown in serum-containing medium differentiated less than cells in serum-free medium due to several factors, including albumin binding of retinoic acid. Addition of an inhi...

Journal: :Journal of lipid research 1980
A C Ross N Adachi D S Goodman

This study reports the isolation and partial characterization of a soluble protein with binding specificity for retinoic acid from rat testis cytosol. Cytosol, labeled in vitro by incubation with [14C]retinoic acid, was fractionated by a series of procedures that included ion exchange chromatography on DEAE-Sepharose and on DEAE-cellulose, gel filtration on Sephadex (G-50, and preparative polya...

Journal: :Development 1993
M W Kelley X M Xu M A Wagner M E Warchol J T Corwin

The mammalian organ of Corti has one of the most highly ordered patterns of cells in any vertebrate sensory epithelium. A single row of inner hair cells and three or four rows of outer hair cells extend along its length. The factors that regulate the formation of this strict pattern are unknown. In order to determine whether retinoic acid plays a role during the development of the organ of Cort...

Journal: :Cancer research 1980
P W Trown A V Palleroni O Bohoslawec B N Richelo J M Halpern N Gizzi R Geiger C Lewinski L J Machlin A Jetten M E Jetten

A new rapid assay has been developed for measurement of the binding of [3H]retinoic acid to cellular retinoic acid-binding protein. The assay, which uses activated charcoal for the separation of bound from unbound retinoic acid, was used to determine the concentration required to inhibit the binding of [3H]retinoic acid to cellular retinoic acid-binding protein by 50% for 18 retinoids with free...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2013
Robert L Redner

Addition of retinoic acid to chemotherapy improves survival of patients with acute myeloid leukemia. This effect is more pronounced in leukemias that express high levels of PRAME. PRAME is an inhibitor of retinoic acid signaling, which may prove to be an important marker for retinoic acid response.

Journal: :Blood 1981
T R Breitman S J Collins B R Keene

The recent finding that retinoic acid induces terminal granulocytic differentiation of the human promyelocytic leukemia cell line, HL-60, prompted an investigation of the sensitivity to this inducer of human myelocytic leukemia cells in primary suspension culture. Of the 21 leukemic specimens, only cells from the two patients with acute promyelocytic leukemia differentiated in response to retin...

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