نتایج جستجو برای: rrms
تعداد نتایج: 1132 فیلتر نتایج به سال:
OBJECTIVE To estimate the incremental change in pharmacy per-member-permonth (PMPM) costs, according to various formulary designs, for a new interferon beta-1a product (IB1a2) using administrative claims data. METHODS Cross-sectional sex- and age-specific disease prevalence and treatment rates for relapsing, remitting multiple sclerosis (RRMS) patients were measured using integrated medical a...
OBJECTIVES The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing-remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. METHODS T1-weighted isotropic brain scans were collected at 3T...
Cognitive dysfunction affects 40-65% of multiple sclerosis (MS) patients and can occur in the early stages of the disease. This study aimed to explore cognitive functions by means of the Italian version of the minimal assessment of cognitive function in MS (MACFIMS) in relapsing-remitting MS (RRMS) patients with very mild clinical disability to identify the primarily involved cognitive function...
PURPOSE To study iron deposition in the substantia nigra (SN) and red nuclei (RN), in patients with clinically isolated syndrome (CIS) and relapsing remitting MS (RRMS) and healthy controls (HC). MATERIALS AND METHODS Iron deposition was assessed using susceptibility maps and T2*-w images acquired at high resolution MRI at 7 Tesla (T). Mean intensities were calculated within circular regions ...
Background Multiple sclerosis (MS) is a chronic, progressive, immune-mediated, neurodegenerative disease of the central nervous system, accumulating patient’s disability over time and causing significant human and economic burden. Approximately 80-90% of the incident MS cases are relapsing-remitting MS (RRMS) characterised by phases of remission and relapse. Important goals of the disease-modif...
BACKGROUND The relationship between white matter injury and cortical atrophy development in relapsing-remitting multiple sclerosis (RRMS) remains unclear. OBJECTIVES To investigate the associations between corticospinal tract integrity and cortical morphology measures of the primary motor cortex in RRMS patients and healthy controls. METHODS 51 RRMS patients and 30 healthy controls underwen...
Laquinimod (ABR-215062) is a new orally available carboxamide derivative, which is currently developed for relapsing remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases. Its mechanism of action may comprise immunomodulatory effects on T-cells, monocytes, and dendritic cells as well as neuroprotective effects with promi...
Soluble forms of nonclassical human leukocyte antigen (HLA)-G have recently been suggested as immunomodulatory factors in multiple sclerosis (MS). HLA-G inhibits the effecter function of T cells and natural killer (NK) cells. Also regulatory T cells (Treg) are considered as pivotal players in MS pathogenesis. Thus, we aimed to evaluate the presence of HLA-G molecules and Treg cells in Relapsing...
BACKGROUND Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease of the CNS in which a pathogenic role of anti-aquaporin-4 (AQP4) antibodies has been suggested. Although AQP4 is expressed in human cortex, recent histologic studies have failed to find any evidence of cortical demyelination in NMO. OBJECTIVE To evaluate, in vivo, the occurrence of focal and diffuse cortical ...
Background: Previous studies suggest that retinal nerve fiber layer (RNFL) thickness decreases over time in multiple sclerosis (MS) and can be a marker of disease activity for patients’ follow-up. Here, we aimed to compare RNFL thickness in patients with relapsing remitting MS (RRMS) during three years of follow-up. Methods: During this prospective study, patients with diagnosis of RRMS and hi...
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