Shortage of transplantable organs available for people with endstage diseases has become goal of scientific project worldwide to find new approaches for providing the needed organs. These projects have mainly focused on complementation of pig embryo genetically manipulated or designed to produce an organ deficient embryo. Considering the fact that pig is not the common domestic animal in Middle...

introduction: mesenchymal stem cells can be isolated from adult tissues, such as the adipose tissue, or other sources. among all these sources, adipose tissue because of easy access, and placenta due to its immunomodulatory properties, in addition to another useful properties, were attracted more attention to themselves. isolation and comparing these two different sources can help us for access...

background: the aim of this study was optimization of the polyfect gene delivery method of pcdna3.1 expression vector transfected with the mouse pdx-1 gene in three different kinds of mesenchymal stem cells and hepa cells as well as comparison of transfection efficiency leading to expression of the mentioned gene in the cell types used. materials and methods: rat bone marrow-derived mesenchymal...

introduction: different effects of low level laser irradiation (llli) on various cell types have already been demonstrated. however, its effects on embryonic stem cells have not yet been shown. the present study evaluates the morphological and immunocytochemical effects of llli on human embryonic stem cell (hesc) colonies. material and methods: equal-sized pieces of hesc line (royan h1) were ir...

Background: The news regarding the successful treatment of uncured diseases is extremely exciting. Recently, the study of stem cells has been widely considered. Objectives: The stem cells have the potential to be converted to all specialized functional cells. Methods: Advances in cell engineering and genetic reprogramming of the stem cells have contributed to novel approaches that may bring h...

background  the mammary gland in humans is a dynamic organ that undergoes significant developmental changes during pregnancy, lactation, and involution. stem cells derived from human breast milk possess the adult stem cell-like characteristics such as self-renewal, proliferative and differentiate potential. this source of stem cells avoids invasive procedures and the ethical controversy of embr...

understanding the molecular mechanisms in regeneration could help the stem cell therapists to improve the clinical practices and could be considered a major milestone in the translation of stem cell research to clinics. chemokines have been described as one of the most significant singling networks in stem cells homing and regeneration of damaged organs. cxcr4/cxcl12 has been known as a key pla...

stem cell-based therapy has great potential in treating health conditions including cardiovascular, autoimmune, type i diabetes, neurodegenerative and bone and cartilage diseases also in spinal cord injuries, malformations and cancer. in addition to their potential use to treat systemic diseases, stem cell-based therapy also provides a powerful tool to treat oral and dental diseases such as cra...

stem cells are self-renewing and undifferentiated cell types that can be differentiate into functional cells. stem cells can be classified into two main types based on their source of origin: embryonic and adult stem cells. stem cells also classified based on the range of differentiation potentials into totipotent, pluripotent, multipotent, and unipotent. multipotent stem cells have the ability...