Hyperthermophilic archaea grow at temperatures that destabilize the primary structure of DNA and in evolutionary terms they are highly divergent from other well studied microorganisms. These prokaryotes should therefore require DNA damage repair to be unusually effective, and could employ novel mechanisms for this repair. Recent genome sequence analyses and biochemical and genetic assays sugges...

The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses th...

introduction: education and training in surgery is in the middle of apprenticeship style of learning especially in operating room with little importance of understanding on how trainees learn. methods: this training is one of the most difficult types of training. medical training and expertise are the specialty of this education system. we can name these complex fields as “operational strategie...

Exploitation of custom-designed nucleases to induce DNA double-strand breaks (DSBs) at genomic locations of choice has transformed our ability to edit genomes, regardless of their complexity. DSBs can trigger either error-prone repair pathways that induce random mutations at the break sites or precise homology-directed repair pathways that generate specific insertions or deletions guided by exo...

Introduction: Acute and chronic rotator cuff tears represent a substantial clinical burden in our society and remain an unsolved problem in orthopaedics. Despite the evolution of minimally-invasive surgical techniques for rotator cuff repair, including mini-open and arthroscopic approaches, failure of surgically repaired rotator cuff tears to heal continues to represent a significant problem. E...

obviously, learning environment plays a crucial role in how second language or a foreign language is learned. in this regard, the importance of interaction for l2 learning has been emphasized. the current study investigated teachers' interactional moves (im) and learners' uptake in efl classrooms systematically. to meet this end, four efl contexts of speaking and listening courses for...

obviously, learning environment plays a crucial role in how second language or a foreign language is learned. in this regard, the importance of interaction for l2 learning has been emphasized. the current study investigated teachers' interactional moves (im) and learners' uptake in efl classrooms systematically. to meet this end, four efl contexts of speaking and listening courses for english m...

Autophagy and DNA repair are biological processes vital for cellular homeostasis maintenance and when dysfunctional, they lead to several human disorders including premature aging, neurodegenerative diseases, and cancer. The interchange between these pathways is complex and it may occur in both directions. Autophagy is activated in response to several DNA lesions types and it can regulate diffe...