The pathogenesis of septic acute renal failure (ARF) involves systemic vasodilation with compensatory upregulation of vasoconstrictors. This can lead to renal vasoconstriction and ARF. Heme oxygenase (HO) is the rate-limiting step in heme metabolism and produces carbon monoxide (CO) and biliverdin. HO-1 is an inducible form of the enzyme and is expressed in response to cell injury. It was hypot...

The authors present the results of follow-up observations children that had undergone neonatal nephropathy. A observation revealed newborns from mothers with chronic kidney diseases are at risk for development nephropathies. long-term positive examination who underwent nephropathy and received a course anti-relapse treatment proved effectiveness renal protection.

Rhesus monkeys (Macaca mulatta) were immunized with purified P fimbriae from Escherichia coli during the last trimester of pregnancy. Infants born of these mothers were compared with those from nonimmunized rhesus mothers. A delay in the onset of renal disease after bladder infection showed protection from passive immunization. This was associated with a high antibody titer in serum. In additio...

1. Serial changes in plasma renin activity and plasma angiotensin levels were followed in rats during acute renal failure induced by mercuric chloride or glycerol. 2. During mercuric chloride-induced acute renal failure there were transitory large increases in plasma renin and angiotensin. In contrast, rats with acute renal failure produced by glycerol had a reduction in plasma renin and angiot...

*Corresponding author: Ali Ghorbani, Department of Nephrology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. E-mail: [email protected] Implication for health policy/practice/research/medical education: The initiation of erythropoietin therapy for the purpose of renoprotection may need to be sooner than that for erythropoiesis, because erythropoietin may...

1. Acute renal failure was induced in conscious rate by subcutaneous injection of glycerol. 2. Expansion of the extracellular space by infusion of 150 mmol/l sodium chloride (saline) partly protected the animals against acute renal failure. 3. This protective effect of saline infusion disappeared when the animals were treated with indomethacin. This effect could be reversed by the addition of p...

BACKGROUND Ischemic preconditioning, a phenomenon induced by brief ischemia and reperfusion periods, renders an organ tolerant to subsequent prolonged ischemia. This study evaluated different schedules of preconditioning the kidney to assess the role of nitric oxide (NO) and determine the effects of preconditioning on kidney transplantation. METHODS In study design A, to determine the optimum...

(1) The vascular permeability factor is present in the renal cortex. This factor has no pressor activity and is quite different from renin. (2) The vascular permeability factor has the characteristics of a protein. Immunoelectrophoretic study reveals a single precipitation line. (3) Administration of the vascular permeability factor to mice causes cerebral hemorrhage. (4) Rabbits subjected to r...