Human red blood cells (RBCs) have remarkable deformability, squeezing through narrow capillaries as small as three microns in diameter without any damage. Several pathological conditions, including malaria, sickle cell disease (SCD), and diabetes can alter the shape and deformability of circulating RBCs. Recent work demonstrates how new computational and analytical models can reveal the ways in...

Embryonic hematopoiesis starts via the generation of primitive red blood cells (RBCs) that satisfy the embryo’s immediate oxygen needs. Although primitive RBCs were thought to retain their nuclei, recent studies have shown that primitive RBCs in mice enucleate in the fetal liver. It has been unknown whether human primitive RBCs enucleate, and what hematopoietic site might support this process. ...

In this paper, the hemoglobin (Hb) re-released from red blood cells (RBCs) and whole blood of 7 carcinoma patients were studied by using electrophoresis release test (ERT), which was established by our lab. Among the 7 carcinoma patients, the re-released Hb was distinctively increased from an intrahepatic bile duct carcinoma patient during one-dimension isotonic ERT. Different from the others, ...

BACKGROUND Although water chambers are often used as surrogate blood-warming devices to facilitate rapid warming of red blood cells (RBCs), these cells may be damaged if overheated. Moreover, filtered and irradiated RBCs may be damaged during the warming process, resulting in excessive hemolysis and extracellular potassium release. METHODS Using hand-held syringes, each unit of irradiated and...

one of the most fundamental components of healthcare system on each country is blood supply chain management. this chain is comprised of two significant components including collecting donor’ bloods and supplying blood’s products. the main purpose of this paper is to concentrate on supplying blood products and present a novel constrained bi-objective mathematical model for a two-echelon blood s...

The aim of the present study was to evaluate the changes in glutathione redox ratio (GSSG·GSH(-1)) in red blood cells (RBCs) and whole blood in well-trained men following a ski marathon. 16 male subjects (27.0 ± 4.7 yrs, 1.81 ± 0.06 m, 77.6 ± 9.6 kg, VO2max 66.2 ± 5.7 ml·kg(-1)·min(-1)) were examined before the competition (pre- COMP), after the competition (post-COMP) and during an 18-hour rec...

Introduction Patients admitted to intensive care units (ICUs) are commonly affected by anaemia, which is contributed to by iatrogenic blood loss from diagnostic testing [1], with potential risks of increasing transfusion requirements and negative effect on outcomes [2]. Recently published guidelines make several recommendations for the management of anaemia and red blood cells (RBCs) transfusio...

Using a novel noncontact technique based on optical interferometry, we quantify the nanoscale thermal fluctuations of red blood cells (RBCs) and giant unilamellar vesicles (GUVs). The measurements reveal a nonvanishing tension coefficient for RBCs, which increases as cells transition from a discocytic shape to a spherical shape. The tension coefficient measured for GUVs is, however, a factor of...

Blood transfusion is one of the most crucial and commonly administered therapeutics worldwide. The need for more accurate efficient ways to manage blood demand supply an increasing concern. Building a technology-based, robust chain that can achieve goals reducing ordering frequency, inventory level, wastage shortage, while maintaining safety usage, essential in modern healthcare systems. In thi...

BACKGROUND We have showed that secretory Apolipoprotein J/Clusterin (sCLU) is down-regulated in senescent, stressed or diseased red blood cells (RBCs). It was hypothesized that sCLU loss relates to RBCs vesiculation, a mechanism that removes erythrocyte membrane patches containing defective or potentially harmful components. METHODOLOGY/PRINCIPAL FINDINGS To investigate this issue we employed...