.. Objectives: The rationale of our study is to investigate whether aspirin alone, or aspirin combined with low molecular weight heparin as compared to placebo (intensive pregnancy surveillance), would improve the live birth rate (primary outcome) among with idiopathic recurrent miscarriages. Secondary outcomes included rate of serious adverse events during pregnancy among pharmacological inter...

BACKGROUND Idiopathic recurrent miscarriage is defined as 3 consecutive pregnancy losses with no contributing features found on investigations. At present there are no treatments of proven efficacy for idiopathic recurrent miscarriage. Uterine natural killer (uNK) cells, the most predominant leucocyte in the endometrium are adjacent to foetal trophoblast cells and thought to be involved in impl...

BACKGROUND Since hypercoagulability might result in recurrent miscarriage, anticoagulant agents could potentially increase the live-birth rate in subsequent pregnancies in women with either inherited thrombophilia or unexplained recurrent miscarriage. OBJECTIVES To evaluate the efficacy and safety of anticoagulant agents, such as aspirin and heparin, in women with a history of at least two mi...

BACKGROUND Recently, the use of granulocyte colony-stimulating factor (G-CSF) has been proposed to improve pregnancy outcomes in reproductive medicine. OBJECTIVE A systematic review of the current use of G-CSF in patients who have difficulty conceiving and maintaining pregnancy was performed. MATERIALS AND METHODS Two electronic databases (PubMed/ Medline and Scopus) were searched. Study se...

Multiple pregnancies account for 3 % of all births. The incidence of triplet pregnancy is 1 in 8,100 pregnancies. However, use of in vitro fertilization and ovulation induction has increased the incidence of multiple pregnancies. The incidence of Mullerian defects in women with recurrent miscarriage is 5–10 % [1] and the incidence in late miscarriage and preterm births is more than 25 % [1]. Th...

Introduction: Recurrent miscarriage is an important health issue. It defined loss of three or more consecutive pregnancies. has multifactorial causes. Platelets (PLT) are generally known as a marker for inflammation and thrombosis. Aim the study: To find association between platelet indices recurrent unexplained miscarriage. Patients Methods: This study was case control conducted at Ain Shams U...

Background: Study question: what is the effect of advanced aged in pregnant women using assisted reproductive technology on the rate of miscarriages? Summary answer: the advanced age effects on the rate of miscarriages. What is known already: It is well known that miscarriage risk increases with age. The proportion of women giving birth after 35 years of age has risen considerably in developing...

The relation of thyroid autoimmunity to miscarriage is an important issue that has attracted the interest of many investigators. A number of papers have been published so far, which include healthy women, women with recurrent miscarriage and those undergoing assisted reproductive techniques. Most studies have shown a significant positive association between the presence of thyroid autoantibodie...

BACKGROUND The prevalence of congenital uterine anomalies in high-risk women is unclear, as several different diagnostic approaches have been applied to different groups of patients. This review aims to evaluate the prevalence of such anomalies in unselected populations and in women with infertility, including those undergoing IVF treatment, women with a history of miscarriage, women with infer...