The present study was designed to investigate the antidiarrheal potential of the methanolic extract of Dillenia indica bark (MDIB). The extract studied for antidiarrheal property using castor oil and magnesium sulphate induced diarrheal model and charcoal induced gastrointestinal motility as well as PGE2-induced enterolooping test in mice. In addition, activities against some causative diarrhea...

PURPOSE Irinotecan (CPT-11) induced diarrhea occurs frequently in patients with cancer and limits its usage. Bacteria β-glucuronidase (GUS) enzymes in intestines convert the nontoxic metabolite of CPT-11, SN-38G, to toxic SN-38, and finally lead to damage of intestinal epithelial cells and diarrhea. We previously reported amoxapine as a potent GUS inhibitor in vitro. To further understand the m...

There are few effective treatment options for radiation-induced dermatitis in breast cancer patients. We conducted a single-arm trial to tested the hypothesis that topical epigallocatechin-3-gallate (EGCG) is effective against radiation-induced dermatitis in breast cancer patients undergoing radiotherapy. Forty-nine patients participated in this study. The patients underwent mastectomy followed...

Providencia alcalifaciens is a member of the family Enterobacteriaceae. There are reports that P. alcalifaciens can cause diarrhea, but the mechanism(s) by which it causes diarrhea is known. We studied P. alcalifaciens isolated from a child and two adults with diarrhea for enteropathogenicity. The three isolates did not exhibit any characteristic adherence to cultured HEp-2 cell monolayers, and...

ABSTRACTIntroduction: Radiotherapy is a cancer therapy that uses ionizing radiation to damage cells. Ionizing in the head and neck area can disrupt function integrity of oral mucosa cause mucositis. In Bandung, prevalence risk factors mucositis (HNC) patients undergoing radiotherapy have not been studied. Some textbooks claim radiotherapy-induced HNC occurs at almost 100%. Various associated wi...

The antidiarrheal effects of the aqueous extract of Punica granatum L. (Punicaceae) peels were evaluated in rats. Studies were carried out on the isolated rat ileum, gastrointestinal motility in vivo, and on castor oil–induced diarrhea in rats. The results revealed that the extract exhibited a concentration-dependent inhibition of the spontaneous movement of the isolated rat ileum and attenuate...

Probiotic bacteria are used to treat or prevent a broad range of human diseases, conditions, and syndromes. In addition, there are areas of medical use that have been proposed for future probiotic applications. Randomized double-blind studies have provided evidence of probiotic effectiveness for the treatment and prevention of acute diarrhea and antibiotic-induced diarrhea, as well as for the p...

Isolate was characterized by biochemical and serological tests. Slide agglutination with typing antisera (Central Research Institute, Kasauli) produced a profile of O: 2,H: a. The isolate was sensitive to ampicillin, ampicillin-sulbactam, amoxicillin-clavulanic acid , tetracycline, chloramphenicol, gentamicin, ofloxacin, amikacin, erythromycin, ciprofloxacin, pefloxacin, and gatifloxacin. The p...

conclusions the application of natural honey is effective in managing and preventing radiation-induced stomatitis in patients with head and neck cancers. results the results showed that severe stomatitis in groups of honey, chamomile and control was 0, 5.7%, and 17.6%, respectively. on the 14th day, it was 0, 0, and 17.6%, respectively. there were significant differences between the three group...

Providencia akalifaciens is a member of the family Enterobacteriaceae. There are reports that P. akalfaciens can cause diarrhea, but the mechanism(s) by which it causes diarrhea is not known. We studied P. akalfaciens isolated from a child and two adults with diarrhea for enteropathogenicity. The three isolates did not exhibit any characteristic adherence to cultured HEp-2 cell monolayers, and ...