A detailed and comprehensive map of the distribution patterns for both natural and artificial radionuclides over Antarctica has been established. This work integrates the results of several decades of international programs focusing on the analysis of natural and artificial radionuclides in snow and ice cores from this polar region. The mean value (37+/-20 Bq m(-2)) of (241)Pu total deposition ...

The need for novel approaches to treat infectious diseases is obvious and urgent. This situation has renewed interest in the use of monoclonal antibodies (mAbs) to treat infectious diseases. During the last 5 years, radioimmunotherapy (RIT), a modality developed for cancer treatment, has been successfully adapted for the treatment of experimental fungal (C. neoformans and H. capsulatum), bacter...

Pancreatic ductal adenocarcinoma (PDAC), a deadly cancer characterized by multiple molecular alterations, remains the most lethal cancer, with 5-year survival rate of about 3–15%. Early diagnosis and treatment monitoring are essential to improve patient survival. Traditional imaging methods can only provide structural information, but not biological processes. Nuclear medicine combines high sen...

INTRODUCTION The use of radionuclides for evaluating thyroid conditions in cats is well documented. Hyperthyroidism is the most common indication. A feature of hyperthyroidism is an increased uptake of radionuclide. The radionuclides most frequently used for thyroidal imaging are I, I, and the pertechnetate ion of technetium (TcO4). The radioisotopes of iodine are exclusively taken up by the th...

The aim of this study was to evaluate acyclic ligands which can be applied for labeling proteins such as monoclonal antibodies and their fragments with scandium radionuclides. Recently, scandium isotopes (47Sc, 44Sc) are more available and their properties are convenient for radiotherapy or PET imaging. They can be used together as "matched pair" in theranostic approach. Because proteins denatu...

Organic compounds contained in radioactive waste can be classified into different categories. The ability of organic compounds to form stable complexes with metallic cations is widely recognized. The effect of Low Molecular Weight (LMW) organic compounds present in the wastes, or produced via their degradation on the mobilization of radionuclides under repository conditions must be assessed. Fo...

Alzheimer's disease (AD) is the most common neurodegenerative disease, with an increasing prevalence. Currently, there no ideal diagnostic molecular imaging agent for diagnosing AD. Antibodies (Abs) have been proposed to close this gap as they can bind selectively and high affinity amyloid β (Aβ)—one of hallmarks Abs even be designed Aβ oligomers or isoforms, which are difficult target small ag...

Background: The presence of radionuclides in the soil, measures need to be taken to minimize the radiation dose to humans. It is mostly gamma-emitting radionuclides that contribute to the radiation dose in long term behavior of these radionuclides in soil may determine the extent to which such countermeasures need to be applied. Materials and Methods: The activity concentration of these radionu...

Tumor glucose metabolism and amino acid metabolism are usually enhanced, 18F-FDG for tumor glucose metabolism PET imaging has been clinically well known, but tumor amino acid metabolism PET imaging is not clinically familiar. Radiolabeled amino acids (AAs) are an important class of PET/CT tracers that target the upregulated amino acid transporters to show elevated amino acid metabolism in tumor...

Introduction Foodstuffs are known to contain natural and artificial radionuclides. Determination of radionuclide concentration is of great significance for the protection of human health. The main objective of the present study was the quantification of radionuclides in tea samples, cultivated in Guilan Province in North of Iran. Materials and Methods The activity concentrations of 226Ra, 232Th...