OBJECTIVES We aimed to study the predictive value of heart rate-corrected QT interval (QTc) for incident coronary heart disease (CHD) and cardiovascular disease (CVD) mortality in the black and white general population, and to validate various QT measurements. BACKGROUND QTc prolongation is associated with higher risk of mortality in cardiac patients and in the general population. Little is k...

Background: Identifying the sources of variation in QTc measurements is important for preventing arrhythmias during and after hemodialysis. The present study was designed to determine the correlation between the type of hemodialysis buffer and the changes in QTc interval in patients on chronic hemodialysis. Methods: Fifty-nine patients on chronic hemodialysis who referred in winter 2007 to hemo...

Background: Azithromycin maintenance therapy is widely used in cystic fibrosis (CF), but little known about its long-term safety. We investigated whether chronic azithromycin use safe regarding renal function, hepatic cell toxicity and QTc-interval prolongation.Methods: Adult CF patients (72 using for a cumulative period of 364.8 years 19 controls, 108.8 years) from two CF-centers the Netherlan...

The interrelationships between serum levels of amiodarone, desethylamiodarone, and reverse T3, and changes in the corrected QT interval (delta QTc) were examined in 22 patients during long-term treatment with amiodarone. At 1, 3, and 6 months of follow-up, the correlation coefficient between serum levels of amiodarone or desethylamiodarone and reverse T3 ranged from 0.01 to -0.2 (p greater than...

OBJECTIVE Our aim was to assess whether severe hypoglycemic attacks were cross-sectionally associated with abnormalities of the QTc interval in type 1 diabetic patients. RESEARCH DESIGN AND METHODS The study included 3,248 type 1 diabetic patients from the EURODIAB IDDM Complications Study. Severe hypoglycemia was defined as an attack serious enough to require the help of another person. A co...

BACKGROUND Intravenous magnesium reduces the QTc interval of patients receiving ibutilide. Whether oral magnesium can reduce the QTc interval associated with oral sotalol and dofetilide is not known. This study was undertaken to evaluate the impact of oral magnesium on the QTc interval and whether an inherent intracellular magnesium deficiency exists among patients with arrhythmias. METHODS P...

BACKGROUND One third of Bahraini adult males and 7.0% of females use all types of tobacco. The prevalence rates of cigarette and shisha smoking are 11.0 and 6.0%, respectively. Tobacco cessation programs are essential to help smokers quit. The objectives of this study were to determine the quit rates among male attendees of quit tobacco clinics (QTC) in Bahrain and describe related factors. M...

The QT interval in the electrocardiogram is the expression of ventricular repolarisation, it is variable in the general population and highly dependent upon heart frequency; therefore, in clinical practice, the QTc index is used, to correct for heart frequency through the well-known Bazzett’s correction formula (QTc=QT/ RR0.5) for heart frequencies below 90 bpm. The QTc index is considered norm...

Objectives: Evaluate electrocardiographic and echocardiographic data in asymptomatic patients affected by Systemic Sclerosis (SSc) compared to healthy subjects, to assess their correlations in a case-control study. Methods: 71 female patients affected by SSc (Group A) were compared to 60 healthy female subjects (Group B). Both patients and controls were evaluated by electrocardiogram and trans-...

BACKGROUND Ramosetron is a relatively new 5-hydroxytryptamine three receptor antagonist with higher binding affinity and more prolonged duration of action compared to ondansetron. The present study was performed to evaluate the effects of ramosetron on QTc interval and possible cardiovascular adverse effects in patients undergoing cardiac surgery. METHOD A total of 114 patients who underwent ...