Proton MR spectroscopy (1H-MR spectroscopy) is a quantitative MR imaging technique often used to complement the sensitivity of conventional MR imaging with specific metabolic information. A key metabolite is the amino acid derivative N-acetylaspartate (NAA), which is almost exclusive to neurons and their processes and is, therefore, an accepted marker of their health and attenuation. Unfortunat...

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases where a lesion is not yet observed in MR images. The collection of molecules used as cerebral biomarkers that are detectable by (1)H NMR spectr...

BACKGROUND AND PURPOSE Sensitivity, positive predictive value (PPV), and negative predictive value (NPV) of conventional MR imaging in predicting glioma grade are not high. Relative cerebral blood volume (rCBV) measurements derived from perfusion MR imaging and metabolite ratios from proton MR spectroscopy are useful in predicting glioma grade. We evaluated the sensitivity, specificity, PPV, an...

Rats and mice may serve as subjects for modeling various pathological conditions, which can be studied by localized MR spectroscopy. In contrast to MR imaging, which relies on properties of water related to its interaction with biomacromolecules, spectroscopy is capable of providing information on concentrations of chemical entities present in a living tissue. Measurements at high magnetic fiel...

MELAS. Evidence for involvement of neurons as well as cerebral vasculature in strokelike episodes. Stroke 1998;27:1420–3. 2 Mizukami K, Sasaki M, Suzuki T, et al. Central nervous system changes in mitochondrial encephalomyopathy: light and electron microscopic study. Acta Neuropathol (Berl) 1992;83:449–52. 3 Abe K, Inui T, Hirono N, et al. Fluctuating MR images with mitochondrial encephalopathy...

BACKGROUND AND PURPOSE Minimal hepatic encephalopathy (MHE) in children is difficult to evaluate because of lack of standardized neuropsychological tests for all age ranges. The purpose of this retrospective study of children with clinically suspected MHE was to investigate relationships between brain MR spectroscopy metabolites and biochemical markers of encephalopathy as well as measures of l...

Three patients with 3-hydroxy-3-methylglutaryl coenzyme A lyase deficiency were examined with MR imaging and proton MR spectroscopy. In two patients, both clinically normal, MR images showed a diffuse mild abnormality in signal intensity of the cerebral white matter, with multiple foci of more pronounced signal abnormality superimposed. In the third patient, who was clinically retarded and had ...

J. Pfeuffer, C. Juchem, H. Merkle, N. K. Logothetis Max Planck Institute for biological Cybernetics, Tuebingen, D, Germany, LFMI, NIH/NINDS, Bethesda, MD, United States First MR spectroscopy results in the anaesthetized and the awake trained monkey (Macaca mulatta) are reported using a novel vertical bore 7T/60cm MR system. The setup was custom-designed for MR imaging and spectroscopy of monkey...