PURPOSE High dose rate (HDR) brachytherapy has been established as an excellent monotherapy or after external-beam radiotherapy (EBRT) boost treatment for prostate cancer (PCa). Recently, dosimetric studies have demonstrated the potential for achieving similar dosimetry with stereotactic body radiotherapy (SBRT) compared with HDR brachytherapy. Here, we report our technique, PSA nadir, and acut...

Heterologous prime-boosting has emerged as a powerful vaccination approach against tuberculosis. However, optimal timing to boost BCG-immunity using subunit vaccines remains unclear in clinical trials. Here, we followed the adhesin Apa-specific T-cell responses in BCG-primed mice and investigated its BCG-booster potential. The Apa-specific T-cell response peaked 32-52 weeks after parenteral or ...

BACKGROUND H5 DNA priming was previously shown to improve the antibody response to influenza A(H5N1) monovalent inactivated vaccine (MIV) among individuals for whom there was a 24-week interval between prime and boost receipt. This study defines the shortest prime-boost interval associated with an improved response to MIV. METHODS We administered H5 DNA followed by MIV at intervals of 4, 8, 1...

This study aimed to evaluate the effects of volume adapted re-planning for radiotherapy (RT) after gross total resection (GTR) for glioblastoma. Nineteen patients with glioblastoma who underwent GTR and postoperative RT were analyzed. The volumes of the surgical cavity on computed tomography (CT) obtained one day after GTR (CT0), the first RT simulation CT (sim-CT1), and the second simulation C...

In this paper presents new topologies Multilevel DC-DC buck-boost converter which consists of an inductor based boost circuit and a switched capacitor circuit has high voltage gain and flexible output voltage. Operation of these switching devices causes inherently nonlinear characteristic to the DC-DC Converters include buck-boost converter. It is suitable for a low voltage power source such as...

New control circuits and algorithms are frequently proposed to control the impedance (Z) source inverter in efficient way with added benefits. As a result, several modified control techniques have been proposed in recent years. Although these techniques are clearly superior to the simple boost control method which was initially proposed along with the Z-source inverter (ZSI), little or conf...