نتایج جستجو برای: poor ovarian response
تعداد نتایج: 1258539 فیلتر نتایج به سال:
PURPOSE We investigated whether inhibition of interleukin 6 (IL-6) has therapeutic activity in ovarian cancer via abrogation of a tumor-promoting cytokine network. EXPERIMENTAL DESIGN We combined preclinical and in silico experiments with a phase 2 clinical trial of the anti-IL-6 antibody siltuximab in patients with platinum-resistant ovarian cancer. RESULTS Automated immunohistochemistry o...
Long protocol of Gonadotropin-Releasing Hormone-analougue (GnRH-a) can result in the formation of ovarian cyst by the transient initial stimulatory effect which increases the levels of both follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These cysts require surgical drainage or result in poor ovarian response. Ovarian cyst formation can be prevented by taking oral contraceptive...
background: evaluation of anti-mullerian hormone (amh) cut-off levels in assisted reproductive technology (art) as predictive factor for individualization of stimulation protocols and to avoid ovarian hyperstimulation syndrome (ohss). materials and methods: in a retrospective study, 177 infertile patients were assessed for amh in serum and follicular fluid (ff) on the day of follicular puncture...
PURPOSE Aurora kinase A (Aurora-A) is known to regulate genomic instability and tumorigenesis in multiple human cancers. The underlying mechanism, however, is not fully understood. We examined the molecular mechanism of Aurora-A regulation in human ovarian cancer. EXPERIMENTAL DESIGN Retrovirus-mediated small hairpin RNA (shRNA) was used to silence the expression of Aurora-A in the ovarian ca...
The hallmarks of ovarian cancer encompass the development of resistance, disease recurrence and poor prognosis. Ovarian cancer cells express gene signatures which pose significant challenges for cancer drug development, therapeutics, prevention and management. Despite enhancements in contemporary tumor debulking surgery, tentative combination regimens and abdominal radiation which can achieve b...
Abstract Background The aim of controlled ovarian stimulation is to achieve an optimal number mature oocytes obtain good-quality embryos. High follicular fluid (FF) concentrations FSH, hCG, and LH promote oocyte maturation are associated with a higher probability fertilization. in FF consistently follicles that will lead successful IVF outcome. levels some these biomarkers may vary among differ...
OBJECTIVE This study aimed to assess a novel protocol designed to improve poor ovarian response through intra-ovarian androgenization. The endpoints were: number of oocytes and mature oocytes retrieved, fertilization, cancellation and pregnancy rates. METHODS This prospective crossover study enrolled poor responders from previous ovarian stimulation cycles submitted to a novel protocol called...
Ovarian cancer is the second most common gynecological malignancy and the leading cause of death from gynecological cancer. Most women present with advanced stage disease, having a poor prognosis even with adequate treatment. Cure is unlikely for advanced disease. Despite the high rate of initial response to chemotherapy, the majority of women will develop recurrent disease, and, thus, new ther...
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