A rapid and sensitive UV-Visible spectroscopic method was developed for the estimation of cefuroxime in pure and its Pharmaceutical formulations. The method was based on the measurement of absorbance of Cefuroxime active moiety of Cefuroxime tablet at 277 nm using methanol as solvent. The absorbance was found to increase linearly with increase in concentration of Cefuroxime which was corroborat...

A simple and rapid RP-HPLC method was developed for quantification of pioglitazone in tablet dosage form. The chromatography system used a reversed phase C8 column with dual wavelength absorbance detection at 267 nm. The mobile phase consisted of acetonitrile and phosphate buffer (pH adjusted to 4.5 using ortho phosphoric acid) in the ratio of 60:40 % v/v at flow rate of 0.8 mL/min. The lineari...

The determination of clopidogrel, an antiplatelet agent, was performed at a gold electrode in pH 3.7 acetate buffer using cyclic voltammetry (CV) and square wave voltammetry (SWV). Each voltammogram was characterized by the well defined peak at approximately 1.0 V. The current of anodic stripping peak exhibited a linear dependence on the clopidogrel concentration in the range from 317.89 to 935...

Characterization of the entire densification process is really difficult by using one simple monovariate equation to be successfully applied in research and development of tablet formulation. Particle rearrangement process can be divided into two steps and described by biexponential Heckel equation. By non-linear approach quantification of compactibility, compressibility and tabletability of th...

A method for determination of alendronate sodium salt, clodronate disodium salt and etidronate disodium salt in pharmaceutical formulation by direct UV-spectrophotometry and/or first and second derivative UV-spectrophotometry via complex formation with Cu (II) ions is described. The calibration graphs are linear in the range 25-600 mmol/L for all the investigated compounds. No interference was ...

A new sensitive, simple, rapid and precise reversed phase high performance liquid chromatographic (HPLC) and a spectrophotometric method has been developed for estimation of tolterodine in tablet dosage form. Chromatography was performed by using the mobile phase, Potassium Phosphate pH 4.5 and acetonitrile mixed by a low pressure gradient program. Hypersil BDS C18 column was used. The waveleng...

A simple, rapid and highly sensitive spectrophotometric method is developed for the determination of risperidone in tablet formulation. The method is based on the oxidation of drug using potassium permanganate in alkaline medium and excess potassium permanganate oxidizes 1,10-phenanthroline Fe(II). The measurement of decrease in absorbance of 1,10-phenanthroline Fe (II) was done at 415 nm. The ...

Chemical imaging with sufficient spatial resolution to resolve microparticles in tablets is essential to ensure high quality and efficacy in controlled release. The existing modalities have the following disadvantages: they are time-consuming or have poor spatial resolution or low chemical specificity. Here, we demonstrate an epi-detected mid-infrared photothermal (epi-MIP) microscope at a spat...