In herbal medicinal products the entire herbal drug or an herbal drug preparation is regarded as the active pharmaceutical ingredient, regardless of whether constituents with defined therapeutic activity are known. In quality control and stability testing of herbal medicinal products, fingerprint chromatograms are used as powerful tools to evaluate and compare the composition of compounds in su...

The possibility of applying main AOP techniques, namely ozonation, H2O2/UV photolysis and TiO2 photocatalysis to provide a significant reduction of toxicity of pharmaceutical mixtures has been evaluated. For the preparation of the mixture six pharmaceuticals were chosen among those found at highest concentrations in Sewage Treatment Plant effluents, namely carbamazepine, clofibric acid, diclofe...

The interest of the pharmaceutical industry in lipid drug delivery systems due to their prolonged release profile, biocompatibility, reduction of side effects, and so on is already known. However, conventional methods of preparation of these structures for their use and production in the pharmaceutical industry are difficult since these methods are usually multi-step and involve high amount of ...

Recombinant gene expression has been the most commonly used method to obtain large quantity of proteins such as enzymes and antigens for pharmaceutical and clinical applications. Although many genes have been efficiently expressed in Escherichia coli, low level of expression and inclusion body formation are still a bottle-neck problem in desired protein production. The expression vectors pHsh a...

Sensitive and reproducible flow injection spectrophotometric method for determination of fluoxetine in pharmaceutical preparation has been developed. The method is based on base hydrolysis of the drug. The hydrolyzed product methylamine is reacted with sodium nitroprusside. The absorbance of the resulting colored product was measured spectrophtometrically at 510 nm using flow injection method. ...