A conference entitled "Towards the establishment of clinical trials in pediatric and newborn stroke" assembled stroke animal model researchers, pediatric stroke researchers, adult stroke trialists, and members of the Food and Drug Administration and National Institute of Neurological Disorders and Stroke to focus on the obstacles and opportunities for conducting randomized trials in pediatric s...

In the last 50 years there has been significant improvement in survival for children with cancer, achieved by implementation of cooperative clinical research trials that found an opportunity to standardize and control treatment childhood cancer. Combined modalities approaches, intensification chemotherapy regimens high-risk disease allow reach 70 % rate all cases. Yet is still a need improve ou...

vancomycin is a a glycopeptide antibiotic with bacetiocidal effects on gram positive bacteria by interfering with cell wall synthesis. the necessity for monitoring of serum vancomycin concentrations (svcs) has been recently noticed at many institutions because of concerns for its nephrotoxicity. we aimed to describe the svcs monitoring in pediatric patients, in an effort to determine subtherape...

BACKGROUND: Optimal management of neutropenic appendicitis (NA) in children undergoing cancer therapy remains undefined. Management strategies include upfront appendectomy or initial nonoperative management. We aimed to characterize the effect strategy on complications and length stay (LOS) describe implications for chemotherapy delay alteration. METHODS: Sites from Pediatric Surgery Oncology R...

Aim: It was a clinical audit conducted over 6 monthsperiod in order to determine the characteristics of healthcare-associated infections (HAIs) immunocompromised children with cancer developing country. Methods: descriptive, cohort study department Pediatric Hematology/Oncology, University Child Health Sciences, The Children’s Hospital Lahore. All patients age less than 16 years, admitted pedia...

Background: Acute lymphoblastic leukemia (ALL) is a prevalent childhood cancer, accounting for approximately 25% of all pediatric cancer cases. The incidence hypertension in ALL patients significantly higher compared to the general population, emphasizing need better understanding and management this condition. aim study was evaluate hematological biochemical factors during induction chemothera...

We will be describing our experience with five patients diagnosed acute lymphoblastic leukemia (ALL), who developed L-Asparaginase (L-Asp)-induced pancreatitis during their remission induction stage. The were treated, at the State Cancer Center of Durango, Mexico (CECAN-Durango) since December 2021, along a group 30 pediatric (in phase treatment) did not develop pancreatitis.

BACKGROUND There exist significant challenges to the receipt of comprehensive oncologic treatment for children diagnosed with cancer in sub-Saharan Africa. To better define those challenges, we investigated treatment outcomes and risk factors for treatment abandonment in a cohort of children diagnosed with cancer at the University Teaching Hospital (UTH), the site of the only pediatric oncology...

Each year, almost 3500 children are diagnosed with leukemia, representing approximately 30% of pediatric cancer cases. Acute lymphoblastic leukemia is the most common form of pediatric leukemia, accounting for approximately 80% of cases. A significant number of children fail to respond to existing chemotherapies or are unable to maintain remission. Their prognosis is poor, with little hope for ...

A review of pediatric breast disorders is provided, with particular attention given to the topics of fibroadenoma, cystosarcoma phylloides, breast infections, breast cancer, and benign breast disease. The pediatric clinician is strongly encouraged to include the breast system as part of a complete examination and educational process.