Introduction. The management of cystic pancreatic lesions has changed in recent years as a result of increasing knowledge of their biological behaviour, better diagnostic options, and international guidelines. Methods. Retrospective analysis of a cohort of 86 patients operated for cystic pancreatic lesions during a seven-year period (2007-2014). Results. Final histopathology revealed 53 intradu...

AIM To describe the indications, technique and outcomes of the novel surgical procedure of duodenum and ventral pancreas preserving subtotal pancreatectomy (DVPPSP). METHODS Data collected retrospectively from 43 patients who underwent DVPPSP and TP between 2009 and 2015 in our single centre were analysed. For enrolment, only patients with low-grade pancreatic neoplasms, such as pancreatic ne...

INTRODUCTION Pancreatic involvement by plasma cell neoplasms is an extremely rare event, with only 50 cases described in the literature. They can present as a primary solitary extramedullary plasmacytoma or plasmacytoma secondary to a plasma cell myeloma. Clinical manifestations are due to the presence of a pancreatic mass usually in the pancreas head, which causes extra-biliary obstruction and...

Background: Promoter hyper-methylation of tumor suppressor genes is a common event that occurs in cancer. As methylation is a reversible modification, agents capable of reversing an abnormal methylation status should help to combat cancer. 5-Aza-CdR is a DNA methyl-transferase inhibitor. The present study aimed to evaluate the effect of 5-Aza-CdR on the proliferation of human pancreatic cancer ...

The activin signaling pathway parallels the transforming growth factor (TGF)-beta pathway. Both use extracellular ligands and cell surface receptors that are structurally and functionally related, as well as the same intracellular mediators (SMADs 2-4) to transmit these signals. Members of both pathways have been characterized previously as tumor suppressor genes on the demonstration of inactiv...

OBJECTIVE To define how patients with pancreatic cysts are being diagnosed and treated. DESIGN Retrospective case series. SETTING University-affiliated tertiary care center. PATIENTS Four hundred one patients evaluated in the Department of Surgery between January 2004 and December 2007. MAIN OUTCOME MEASURES Clinical management, histological diagnosis, and results of surveillance. RES...

Pancreatic Endocrine Tumors (PNETs) represent a rare, but important subset of pancreatic neoplasms. These tumors account for 2–4% of all clinically detected pancreatic tumors. Their overall incidence is approximately 1 of 100 000 people per year [1,2]. PNETs consist of single or multiple benign or malignant neoplasms and are associated with multiple endocrine neoplasia type 1 (MEN1) in 10– 20% ...

Abstract Background The prognostic values of inflammation-based markers in well-differentiated pancreatic neuroendocrine neoplasms, diagnosed according to the new 2017 World Health Organization classification, have remained unclear. Therefore, we assessed ability predict recurrence such after curative resection patients with these neoplasms. Methods Circulating/systemic neutrophil–lymphocyte, m...

Extramedullary plasmacytomas are plasma cell neoplasms in organs other than the bone marrow. Most are found in the upper respiratory tract. Involvement of the pancreas is rare. We report a case of pancreatic plasmacytoma in association with advanced multiple myeloma.

OBJECTIVE The objectives of this analysis were to define the incidence, natural history, and predictors of neoplasia in pancreatic cysts to determine which patients can safely be observed and which should undergo an operation. SUMMARY BACKGROUND DATA With advancements in imaging technology, cystic lesions of the pancreas are being detected with increased frequency. Many of these lesions are s...