نتایج جستجو برای: paget
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signed by Lord Herschell, the Chairman; Judge Meadows White, Q.C.; Mr. John S. Dugdale, Q.C.; Sir Edwin Galsworthy, Chairman of the Metropolitan Asylums Board ; Sir Charles Dalrymple, M.P.; Mr. Samuel Whitbread, exM.P.; and Mr. John A. Bright, ex-M.P. It is also signed by the following members of the medical profession : Sir James Paget, Bart.; Sir W. Guyer Hunter, ex-M.P.; Prof. Michael Foster...
∗ Corresponding author. E-mail: [email protected] (H. Husein-ElAhmed). PD of the nipple is an uncommon disease accounting for approximately 1–3% of all cases of breast carcinoma.1,2 This condition is a rare malignancy of the breast characterized by infiltration of the epidermis of the nipple with malignant cells known as “Paget cells”. These cells are large, round or ovoid, with clear, ...
SQSTM1 mutations, coding for the p62 protein, were identified as a monogenic cause of Paget disease of bone and of amyotrophic lateral sclerosis. More recently, SQSTM1 mutations were identified in few families with frontotemporal dementia. We report a new family carrying SQSTM1 mutation and presenting with a clinical phenotype of speech apraxia or atypical behavioral disorders, associated with ...
Bisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we repor...
P disease of the bone, first described in 1877 by Sir James Paget, is an extreme example of disordered bone remodeling.1 Disordered bone structure, due to the marked increase in osteoclastic activity and bone resorption, followed by excessive bone formation, is a characteristic of Paget’s disease. This may lead to pain, fracture and deformity. Pagetic bone is highly vascular and contains excess...
TDP-43 mislocalization and aggregation are implicated in the pathogenesis of ALS and FTLD-U. Valosin containing protein (VCP) mutations also lead to TDP-43 deposition, resulting in Inclusion Body Myopathy, Paget disease, and Frontotemporal Dementia (IBMPFD). In this issue of Neuron, Johnson et al. used whole-exome capture to identify VCP mutations in familial ALS. This extends the VCP phenotype...
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