نتایج جستجو برای: p53 expression

تعداد نتایج: 898809  

Journal: :Molecular pathology : MP 1997
M A Villaseca I Roa J C Araya J C Roa P Flores

AIMS To examine the relation between the expression of p53 protein and the chaperone heat shock protein (hsp)72/73 in a population at high risk for gastric carcinoma, using single and double immunohistochemistry, and to compare the expression of these two proteins with clinicopathological features. METHODS Monoclonal antibodies were used to investigate the expression of p53 protein and hsp72/...

2015
JUN CHEN FANG WU HONG-LEI PEI WEN-DONG GU ZHONG-HUA NING YING-JIE SHAO JIN HUANG

The present study aimed to explore the importance of P53 and Cox-2 protein expression in esophageal cancer and assess their influence on prognosis. The expression of P53 and Cox-2 was assessed in esophageal cancer samples from 195 patients subjected to radical surgery at Changzhou First People's Hospital (Changzhou, China) between May 2010 and December 2011. Expression of P53 and Cox-2 proteins...

Journal: :Voprosy onkologii 2022

Aim. We aim to compare immunophenotypic characteritics of atypical epithelium (AE) with COVID-19-induced diffuse alveolar damage (DAD) and pulmonary lepidic-growth adenocarcinoma, accounting for cell cycle control, proliferation differentiation]. Methods. examined tissue specimens from twenty-four fatal cases acute respiratory syndrome confirmed by autopsy (Group 1) four adenocarcinoma 2). Perp...

Journal: :Cancer research 1996
D A Greenhalgh X J Wang L A Donehower D R Roop

To investigate the effect of p53 tumor suppressor gene loss in the mouse skin model of multistage carcinogenesis, p53 knockout mice, generated by gene targeting (p53 -/-), were mated to transgenic mice expressing v-rasHa (HK1.ras), v-fos (HK1.fos), or human transforming growth factor alpha+HK1.TGFalpha) exclusively in the epidermis, by means of a keratin K1-based targeting vector (HK1). HK1-p53...

Journal: :Oncology reports 2014
Deyao Xie Linhua Lan Kate Huang Lin Chen Cuicui Xu Rongrong Wang Yang Shi Xiaoyi Wu Lu Wang Yongzhang Liu Bin Lu

Non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all lung cancer cases. Cigarette smoking is the number one risk factor which is attributed to more than four out of five cases of lung cancers. The prognostic impact of cell cycle regulation-associated tumor suppressors including p53 and p21 for NSCLC is still controversial. In the present study, we examined p53 and p21 exp...

2003
Young-Ho Seo Young-Eun Joo Sung-Kyu Choi Jong-Sun Rew Chang-Soo Park Sei-Jong Kim

BACKGROUND Cyclin-dependent kinase inhibitors (CDKI), including p21, p27 and p57 of the KIP family, are negative regulators of cell cycle progression and potentially act as tumor suppressors. The expression of p21 is induced by tumor suppressor gene p53. Mutations of p53 are common and found in various human cancers. Thus, the function of p21 as a tumor suppressor may be not retained after p53 ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Yaguang Xi Reut Shalgi Oystein Fodstad Yitzhak Pilpel Jingfang Ju

PURPOSE The aim of this study was to investigate the role of p53 in regulating micro-RNA (miRNA) expression due to its function as a transcription factor. In addition, p53 may also affect other cellular mRNA gene expression at the translational level either via its mediated miRNAs or due to its RNA-binding function. EXPERIMENTAL DESIGN The possible interaction between p53 and miRNAs in regula...

Journal: :Molecular cancer research : MCR 2009
Wai Fook Leong Jenny Fung Ling Chau Baojie Li

p53-p21-cyclin-dependent kinase and p16(INK4a)-cyclin-dependent kinase pathways have parallel functions in preventing tumorigenesis. In cancer patients, tumor suppressor p53 is frequently inactivated through mutations, whereas p16(INK4a) is silenced through promoter methylation. However, the interaction between these two pathways is less well understood. Here, we report that p53 controls p16(IN...

2017
Haojie Liu Ming Zhou

OBJECTIVE The objective of this study was to evaluate the correlation between the expression of p53 gene and the prognosis after local excision in uveal melanoma. MATERIALS AND METHODS Real-time polymerase chain reaction (RT-PCR) test and Western blot were used to detect the expression of p53 in C918, MUM-2B, and D78 cell lines at the levels of messenger RNA (mRNA) and protein. Immunohistoche...

Journal: :gastroenterology and hepatology from bed to bench 0
rouhallah najjar sadeghi pedram azimzadeh mohsen vahedi mahsa molaei seyed reza mohebbi homayon zojaji

aim : the purpose of this study was to assess the incidence of 16bp insertion of intron 3 p53 in gastritis lesion and its correlation with clinicopathological aspects. background : p53 alterations have been implicated in the development of gastric malignancies. patients and methods : 97 gastritis and normal adjacent tissues were investigated for p53 gene analysis using pcr-sequencing of intron3...

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