Demineralized bone matrix has been successfully commercialized as an alternative bone graft material that not only can function as filler but also as an osteoinductive graft. Numerous studies have confirmed its beneficial use in clinical practice. Heterotopic ossification after internal fixation combined with the use of demineralized bone matrix has not been widely reported. In this paper we de...

The ideal biomaterials substitute for bone repair should possess the following characteristics: provide osteogenic, osteoinductive and osteoconductive properties; stimulate neo-angiogenesis process; absence of antigenic, teratogenic or carcinogenic reactions; avoid systemic toxicity complications; assure satisfactory support stability from mechanical properties point view; hydrophilic nature su...

Despite bone’s inherent ability to heal, large bone defects remain a major clinical concern. This study proposes an off-the-shelf treatment combining chitosan/hydroxyapatite (CS/HAp) scaffolds, covalently linked with either morphogenetic protein-2 (BMP-2) or its related peptide P28 via UV crosslinking process. Although binding the growth factors was reported as great alternative conventionally ...