Methods 70 CTO patients without any other relevant coronary artery stenosis (or already treated if present at baseline angiography), underwent an adenosine stress CMR before a reopening attempt. ECG and echocardiographic (echo) data were available for all. Patients were considered suitable for the reopening procedure in case of myocardial ischemia and / or viable myocardium subtended to the CTO...

The technique of sampling exhaled air is attractive because it is noninvasive and so allows repeated sampling with ease and no risk for the patient. Knowledge of the biomarkers' origin is important to correctly understand and interpret the data. Endogenous particles, formed in the airways, are exhaled and reflect chemical composition of the respiratory tract lining fluid. However, the formation...

The d-Ala:d-Lac ligase, VanA, plays a critical role in the resistance of vancomycin. Indeed, it is involved in the synthesis of a peptidoglycan precursor, to which vancomycin cannot bind. The reaction catalyzed by VanA requires the opening of the so-called "ω-loop", so that the substrates can enter the active site. Here, the conformational landscape of VanA is explored by an enhanced sampling a...

P eustachian tube (pET) is a rare but disabling condition in which the cartilaginous portion of the ET is open at rest. Normally, the tube valve remains closed, opening transiently during swallow and yawn. Patients with pET describe autophony, aural fullness, and hearing one’s own physiological sounds such as swallowing and respiration. Imbalance can also occur along with these other symptoms. ...

In this paper the dynamic location problem with opening, closure and reopening of facilities is formulated and an efficient primal-dual heuristic that computes both upper and lower limits to its optimal solution is described. The problem here studied considers the possibility of reconfiguring any location more than once over the planning horizon. This problem is NP-hard (the simple plant locati...

Airways that collapse during deflation generate a crackle sound when they reopen during subsequent reinflation. Since each crackle is associated with the reopening of a collapsed airway, the likelihood of an airway to be a crackle source is identical to its vulnerability to collapse. To investigate this vulnerability of airways to collapse, crackles were recorded during the first inflation of s...

Osmoregulation in guard cells of intact, attached Vicia faba leaves grown under growth chamber and greenhouse conditions was studied over a daily light cycle of stomatal movements. Under both growth conditions guard cells had two distinct osmoregulatory phases. In the first (morning) phase, opening was correlated with K+ uptake and, to a lesser extent, sucrose accumulation. In the second (after...

The article presents a method for determining the size of supply and exhaust openings to ensure effective aeration barn in calm weather. results multivariate calculations ventilation air flow rates two modes are given: with organization slot full opening openings.

We measured the input-output properties of the hand grasps of 14 individuals with tetraplegia at the C5/C6 level who had received an implanted upper limb neuroprosthesis. The data provide a quantitative description of grasp-opening and grasp-force control with neuroprosthetic hand grasp systems. Static properties were estimated by slowly ramping the command (input) from 0 to 100%. A hand-held s...